Regeneration of the periodontal ligament in ankylosed teeth by in vivo electroporation

为从分子细胞水平阐明强直牙牙周膜的病理生理机制，本研究采用大鼠磨牙咬合功能减退模型，观察了IGF-1（细胞生长因子）、bFGF（成纤维细胞生长因子）和VEGF（血管内皮生长因子）在强直牙牙周膜中的表达。我们还研究了SNS（交感神经系统）/卵巢切除对咬合功能减退所致大鼠牙槽骨丢失的影响，因为强直牙的病理生理与牙槽骨重建密切相关。

To elucidate the pathophysiology of periodontal ligament in the ankylosed tooth at a molecular cell level, we revealed patterns of expression of IGF-1 (cell growth factor) , bFGF (fibroblast growth factor) and VEGF (vascular endothelial growth factor) using by occlusal hypofunction model in rat molars region. We also examined effects of SNS(sympathetic nervous system)/ovariectomy on alveolar bone loss induced by occlusal hypofunction in rats, because the pathophysiology of the ankylosed tooth was much concerned to alveolar bone remodeling.