Regeneration of the periodontal ligament in ankylosed teeth by in vivo electroporation

体内电穿孔促进强直牙齿牙周膜再生

• 批准号: 20592390
• 负责人: KANEKO Sawa
• 金额: $ 2.91万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592390/
• 关键词: 骨性癒着; 歯根膜; 再生; in vivo electroporation; 石灰化抑制因子; 再植

To elucidate the pathophysiology of periodontal ligament in the ankylosed tooth at a molecular cell level, we revealed patterns of expression of IGF-1 (cell growth factor) , bFGF (fibroblast growth factor) and VEGF (vascular endothelial growth factor) using by occlusal hypofunction model in rat molars region. We also examined effects of SNS(sympathetic nervous system)/ovariectomy on alveolar bone loss induced by occlusal hypofunction in rats, because the pathophysiology of the ankylosed tooth was much concerned to alveolar bone remodeling.

为了在分子细胞水平上阐明强直牙牙周韧带的病理生理机制，我们利用咬合功能低下模型揭示了大鼠磨牙区IGF-1（细胞生长因子）、成纤维细胞生长因子（bFGF）和血管内皮生长因子（VEGF）的表达模式。我们还研究了交感神经系统/卵巢切除术对大鼠咬合功能低下引起的牙槽骨丢失的影响，因为强直牙的病理生理与牙槽骨重塑密切相关。

项目成果

Influence of occlusal stimuli on the microvasculature in rat dental pulp

• 发表时间: 2009
• 作者: 渋谷 直樹

Changes in the Distribution of Nerve Fibers Immunoreactive to Calcitonin Gene-Related Peptide According to Growth and Aging in Rat Molar Periodontal Ligament

• DOI: 10.2319/040109-185.1
• 发表时间: 2010-03-01
• 期刊: ANGLE ORTHODONTIST
• 影响因子: 3.4
• 作者: Jung, Hangsul;Horiuchi, Mariko;Soma, Kunimichi
• 通讯作者: Soma, Kunimichi

Influences of occlusal stimuli on the expression of IGF-1 and IGF-1 receptor inthe rat periodontal ligament.

咬合刺激对大鼠牙周膜IGF-1及IGF-1受体表达的影响

• 发表时间: 2008
• 期刊: Angl Orthodontist. 78
• 作者: Saewadee Termsuknirandorn;Jun Hosomichi,Kunimichi Soma.
• 通讯作者: Jun Hosomichi,Kunimichi Soma.

咬合刺激低下時における歯槽骨代謝に交感神経系が与える影響について

咬合刺激减少时交感神经系统对牙槽骨代谢的影响

• 发表时间: 2010
• 作者: 清水康広;細道純;金香佐和;小野卓史
• 通讯作者: 小野卓史

Alteration of bFGF expression with growth and age in rat molar periodontal ligament

• DOI: 10.2319/011910-38.1
• 发表时间: 2010-09-01
• 期刊: ANGLE ORTHODONTIST
• 影响因子: 3.4
• 作者: Sako, Emi;Hosomichi, Jun
• 通讯作者: Hosomichi, Jun