Experimental analysis of the induction mechanism of atherosclerosis by oral biofilm bacteria as a possible new risk factor
Experimental analysis of the induction mechanism of atherosclerosis by oral biofilm bacteria as a possible new risk factor
批准号:
20592459
负责人:
NAGATA Emi
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Oral viridans group streptococci are the major commensal bacteria of the supragingival oral biofilm and have been detected in human atheromatous plaque. The oral streptococci tested were capable of invading HAECs. HAECs invaded by one of four kinds of oral streptococci including cariogenic bacterium produced more cytokine(s) than non-invaded HAECs. These results suggest that oral streptococci may participate in the pathogenesis of atherosclerosis.
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Production of inflammatory cytokines by HAECs invaded by oral streptococci.
口腔链球菌侵入的 HAEC 产生炎症细胞因子。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Nagata E., de Toledo A., Oho T.]
通讯作者:
Oho T.
口腔レンサ球菌のヒト動脈内皮細胞への侵入および炎症反応誘導について
口腔链球菌侵入人动脉内皮细胞并诱导炎症反应
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[長田恵美, de Toledo A., 於保孝彦]
通讯作者:
於保孝彦
DOI:
10.1111/j.2041-1014.2010.00597.x
发表时间:
2011-01-01
期刊:
MOLECULAR ORAL MICROBIOLOGY
影响因子:
3.7
作者:
[Nagata, E., de Toledo, A., Oho, T.]
通讯作者:
Oho, T.
Production of Inflammatory Cytokines by HAECs Invaded by Oral Streptococci
口腔链球菌入侵的 HAEC 产生炎症细胞因子
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Nagata E., de Toledo A., Oho T., Nagata E.]
通讯作者:
Nagata E.
Streptococcus anginosus L-cysteine desulfhydrase gene expression is associated with abscess formation in BALB/c mice
BALB/c小鼠中咽峡炎链球菌L-半胱氨酸脱硫酶基因表达与脓肿形成相关
DOI:
--
发表时间:
2011
期刊:
Mol. Oral Microbiol
影响因子:
--
作者:
[Takahashi Y., Yoshida A., Nagata E., HoshinoT., Oho T., Awano S., Takehara T., Ansai T]
通讯作者:
Ansai T
共 8 条
Invasive Streptococcus mutans induces inflammatory cytokine production of human aortic endothelial cells via regulation of TLR2 and NOD2
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批准号:23593094
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.24万
-
财政年份:2011
-
负责人:NAGATA Emi
-
依托单位:
Experimental aspiration pneumonia induced by human supragingival dental plaque in mice
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批准号:17592185
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2005
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负责人:NAGATA Emi
-
依托单位:
Experimental infective endocarditis induced by human supragingival dental plaque
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批准号:15592211
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.18万
-
财政年份:2003
-
负责人:NAGATA Emi
-
依托单位:
海外基金