Experimental analysis of the induction mechanism of atherosclerosis by oral biofilm bacteria as a possible new risk factor

口腔生物膜细菌作为可能的新危险因素诱导动脉粥样硬化机制的实验分析

• 批准号: 20592459
• 负责人: NAGATA Emi
• 金额: $ 2.83万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592459/
• 关键词: 口腔細菌; バイオフィルム; 感染症; 動脈硬化; 歯学; 細菌

Oral viridans group streptococci are the major commensal bacteria of the supragingival oral biofilm and have been detected in human atheromatous plaque. The oral streptococci tested were capable of invading HAECs. HAECs invaded by one of four kinds of oral streptococci including cariogenic bacterium produced more cytokine(s) than non-invaded HAECs. These results suggest that oral streptococci may participate in the pathogenesis of atherosclerosis.

口腔绿色链球菌是牙周上生物膜的主要共生菌，已在人类动脉粥样硬化斑块中检出。被测试的口腔链球菌能够侵袭血管内皮细胞。含致龋菌在内的4种口腔链球菌侵袭的HAECs产生的细胞因子(S)比未侵袭的HAECs多。提示口腔链球菌可能参与动脉粥样硬化的发病机制。

项目成果

Production of inflammatory cytokines by HAECs invaded by oral streptococci.

口腔链球菌侵入的 HAEC 产生炎症细胞因子。

• 发表时间: 2010
• 作者: Nagata E.;de Toledo A.;Oho T.
• 通讯作者: Oho T.

口腔レンサ球菌のヒト動脈内皮細胞への侵入および炎症反応誘導について

口腔链球菌侵入人动脉内皮细胞并诱导炎症反应

• 发表时间: 2009
• 作者: 長田恵美;de Toledo A.;於保孝彦
• 通讯作者: 於保孝彦

Invasion of human aortic endothelial cells by oral viridans group streptococci and induction of inflammatory cytokine production

• DOI: 10.1111/j.2041-1014.2010.00597.x
• 发表时间: 2011-01-01
• 期刊: MOLECULAR ORAL MICROBIOLOGY
• 影响因子: 3.7
• 作者: Nagata, E.;de Toledo, A.;Oho, T.
• 通讯作者: Oho, T.

Production of Inflammatory Cytokines by HAECs Invaded by Oral Streptococci

口腔链球菌入侵的 HAEC 产生炎症细胞因子

• 发表时间: 2010
• 作者: Nagata E.;de Toledo A.;Oho T.;Nagata E.
• 通讯作者: Nagata E.

Streptococcus anginosus L-cysteine desulfhydrase gene expression is associated with abscess formation in BALB/c mice

BALB/c小鼠中咽峡炎链球菌L-半胱氨酸脱硫酶基因表达与脓肿形成相关

• 发表时间: 2011
• 期刊: Mol. Oral Microbiol
• 作者: Takahashi Y.;Yoshida A.;Nagata E.;HoshinoT.;Oho T.;Awano S.;Takehara T.;Ansai T
• 通讯作者: Ansai T