Elucidation of relationship between indole produced in periodontopathogenic bacteria and periodontal disease

为了阐明牙龈卟啉单胞菌、、核梭杆菌和中间普氏杆菌产生吲哚的分子机制，我们对编码与吲哚产生相关的色氨酸酶的TNAA进行了转录分析，并对纯化的蛋白进行了酶学性质研究。我们还阐明了吲哚对核盘藻生物膜形成的诱导作用。此外，作为吲哚生产底物的色氨酸也被认为可以促进微生物生物膜的形成。

To elucidate the molecular mechanism to produce indole in Porphyromonas gingivalis、Fusobacterium nucleatum, and Prevotella intermedia, we carried out the transcriptional analyses of tnaA encoding tryptophanase associated with indole production and enzymatic characterization of the purified protein. We also clarified induction of F. nucleatum biofilm formation by indole. In addition, tryptophan that is a substrate for indole production was also suggested to promote biofilm formation of the microorganism.