Elucidation of metabolites from periodontopathogenic bacteria on their biofilm formation and virulence.

包括吲哚在内的甲硫氨酸对细菌生物膜的形成有影响。本研究对产吲哚的黄原胶酶进行了研究。对牙周致病菌中间普雷沃菌的色氨酸酶进行了分离纯化和酶学性质研究。此外，在22种普氏菌中检测了产生吲哚的能力和编码β-葡聚糖酶的基因的存在。此外，还研究了降解和产生环状二核苷酸的蛋白质。

Metabolites, including indole, have an effect on bacterial biofilm formation. In this study, study on tryptophanase producing indole was performed. Tryptophanase of Prevotella intermedia, which is one of periodontopathogenic bacteria, was purified and enzymatically characterized. In addition, capacity to produce indole and existence of the gene encoding tryptophanase were examined in 22 Prevetella species. Also, proteins to degrade and produce cyclic-di-nucleotides also investigated.