Prevention of stomatitis associated with cancer chemotherapy by rinsing and gargling with cevimeline hydeochroride hydrate solution

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We investigated the influence on oral mucosa directly from the patients who were to receive cancer chemotherapy. We examined first the features of stomatitis depending on the chemotherapy regimen. It showed that the patients experienced dry mouth first followed by taste disturbances and stomatitis. Then, we hypothesized that preventing dry mouth would preclude such patients from getting mucositis. Cevimeline hydeochroride hydrate (CHH) is a drug to stimulate saliva secretion which may be an ideal agent to prevent dryness of the mouth. Then we conducted the study in healthy individuals to investigate the effects and toxicity profiles of this agent. The amount of saliva was increased during and even after gargle with CHH with no discernible toxicity. Then, we performed a sequential study, i.e. the patients who received chemotherapy with CHH gargle for the first cycle and then with no CHH for the next cycle. It is suggested that gargle with CHH is a good candidate to prevent stomatitis in patients receiving cytotoxic chemotherapeutic agents.