Activated mechanism in the neuroplasticity change of nitric oxide, which is a diagnosis and the candidate of the treatment index

由神经系统损伤或功能障碍引起的神经性疼痛是一种常见的严重致残状态，影响着全世界数百万人。Fyn激酶介导的NMDA受体NR2B亚基在背角Tyr1472位点的磷酸化可能在突触后密度中NMDA受体的保留和一氧化氮合酶的激活中具有双重作用。Tyr1472位点敲入苯丙氨酸突变的Y1472F-KI小鼠没有表现出L5脊神经横断引起的神经性疼痛。

Neuropathic pain produced by damage to or dysfunction of the nervous system is a common and severely disabling state that affects million of people worldwide. Fyn kinase-mediated phosphorylation of NR2B subunits of NMDA receptors at Tyr1472 in the dorsal horn may have dual roles in the retention of NMDA receptors in the postsynaptic density and in activation of nitric oxide synthase. Y1472F-KI mice witha knock-in mutation of the Tyr1472 site to phenylalanine did not exhibit neuropathic pain induced by L5 spinal nerve transection.