Design, Synthesis and Biological Application of Chemical Probes for in vivo Imaging

后基因组时代的一大挑战是阐明活细胞中直接存在的细胞内分子的生物学意义。如果我们可以在体内可视化一个分子，就有可能获得生物信息，而如果我们处理细胞匀浆，这是无法获得的。一种可能的方法是设计和合成能够将生物信息转化为化学输出的化学探针。开发了具有可调开关的新型核磁共振探针和用功能分子标记目标蛋白质的新方法。

One of the great challenges in the post-genome era is to clarify the biological significance of intracellular molecules directly in living cells. If we can visualize a molecule in vivo, it is possible to acquire biological information, which is unavailable if we deal with cell homogenates. One possible approach is to design and synthesize chemical probes that can convert biological information to chemical output. Novel MRI probes with tunable switches and novel methods to label target proteins with functional molecules are developed.