Systems evolutionary analysis on Hox transcription networks in the early embryonic development

我们发现，在后生动物胚胎的系统发育阶段，HOX转录网络在调节前后轴的模式方面起着关键作用。我们从公共基因表达数据库中检索到HOX调控基因的启动子和解剖结构，并对其进行了生物信息学分析。然后，我们比较了小鼠、海鞘和果蝇之间的Hox转录网络。

We identified Hox transcriptional networks which have key roles in regulating the patterning of the antero-posterior axis at phylotypic stage in a metazoan embryo. We conducted bioinformatics methods including promoter analysis on Hox regulating genes in each evolutionary stage and anatomical structure which were retrieved from public gene expression database. We then compared Hox transcriptional networks among mouse, sea squirt, and fruit fly.