The neuronal plasticity in the spinal dorsal horn revealed by simultaneous imaging of neuronal and glial activity
The neuronal plasticity in the spinal dorsal horn revealed by simultaneous imaging of neuronal and glial activity
批准号:
20700348
负责人:
IKEDA Hiroshi
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
本实验观察了大鼠脊髓背角神经胶质细胞的形态学变化、神经胶质细胞对神经元兴奋的贡献以及神经胶质细胞活性的变化,特别是P2 X4受体的变化。在神经病理性疼痛中,激活的小胶质细胞数量增加,P2 X 4受体介导的Ca ~(2+)信号增强,单脉冲刺激引起的神经元兴奋被胶质细胞抑制剂或P2 X受体拮抗剂抑制。
英文摘要
In this study, we examined the change of morphology of glial cells, the contribution of glial cells to the neuronal excitation and the change of glial activity especially P2X4 receptors in the rat spinal dorsal horn under hyperalgesia. In the neuropathic pain, the number of activated form of microglia and the Ca2+ signals via P2X4 receptor are increased, and the neuronal excitation evoked by single-pulse stimulation was decreased glial inhibitor or P2X receptor antagonist.
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Pain-related fear and imaging brain activity.
与疼痛相关的恐惧和大脑活动成像。
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Hasegawa T, Ikeda H, Murase K]
通讯作者:
Murase K
Glia-mediated facilitation of neuronal excitation in the spinal dorsal horn in arthritic rats
胶质细胞介导的关节炎大鼠脊髓背角神经元兴奋的促进
DOI:
--
发表时间:
2008
期刊:
Pain Research 23
影响因子:
--
作者:
[Ikeda H, Nishi R, Murase K.]
通讯作者:
Murase K.
DOI:
10.1186/1744-8069-4-39
发表时间:
2008-09-26
期刊:
MOLECULAR PAIN
影响因子:
3.3
作者:
[Ikeda, Hiroshi, Kiritoshi, Takaki, Murase, Kazuyuki]
通讯作者:
Murase, Kazuyuki
The effect of odor on anxiety and c-Fos expression in the brain
气味对焦虑和大脑中 c-Fos 表达的影响
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Tanaka T, Ikeda H, Murase K]
通讯作者:
Murase K
Change in anxious behavior and the c-Fos expression in the brain by a plant-derived fragrance
植物芳香剂改变大脑中的焦虑行为和 c-Fos 表达
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Asakawa Y, Ikeda H, Murase K]
通讯作者:
Murase K
共 26 条
Conceptualization and determinants of followership in work organizations: Toward the development of effective followership
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批准号:16K04282
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The range expansion pattern and ecologial release of invasive soil invertebrates
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"One-Electron Sigma Bond" - A Challenge to a New Theory of the Chemical Bond Developed by Using Radical Cations
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批准号:24655037
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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Application of fractal on huge surface area of porous materials
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批准号:24760564
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项目类别:Grant-in-Aid for Young Scientists (B)
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财政年份:2012
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Systematic analyses for the Pan-Himalayan flora based on genetical and species diversities
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批准号:23255005
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$18.64万
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财政年份:2011
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The mechanism of hyperalgesia in the spinal dorsal horn revealed by imaging of neuronal activity
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批准号:22600005
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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Phylogeographical study on widely-distributed and local endemicspecies
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批准号:22570085
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2010
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A Challenge to "Organic Radical Light-emitting Diode" Utilizing Stable Radicals
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批准号:21655016
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.21万
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财政年份:2009
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负责人:IKEDA Hiroshi
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A study on the modeling theory pertaining to the sources of developing confidence towards employment
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批准号:20730410
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.25万
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财政年份:2008
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负责人:IKEDA Hiroshi
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依托单位:
Elucidation of mechanism for thermoluminescence of reactive organic radicals and development of new light-emitting systems.
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批准号:19350025
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资助金额:$12.98万
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财政年份:2007
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依托单位:
Construction of molecular recognition systems based on sensor array using functional hosts
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批准号:18550120
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.64万
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财政年份:2006
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负责人:IKEDA Hiroshi
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依托单位:
Development of cryogenic regenerator by perovskite oxide samples
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批准号:18560671
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资助金额:$2.34万
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Study on the cognitive and behavioral consequences of prenatal or early developmental exposure of the brain to ethanol
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依托单位:
Does ethanol-induced lipid metabolism dysfunction aggravate symptoms of dementia?
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批准号:14570936
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2002
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Construction of a substrate transfer system of which binding abilities can synchronize with environmental change
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批准号:14550820
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Investigation of reactivity of organic radical cations in solution and at interface.
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批准号:14050008
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$17.73万
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财政年份:2001
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负责人:IKEDA Hiroshi
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Grobner asymptotic expansion for regular holononic systems
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批准号:10440044
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$2.88万
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财政年份:1998
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负责人:IKEDA Hiroshi
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依托单位:
Construction and Application of Supramolecular Assembles Having Regulation Systems for Their Activities
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批准号:10650844
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.43万
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财政年份:1998
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负责人:IKEDA Hiroshi
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依托单位:
Comparative Research on Minority Education in Japan and U.S.
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批准号:06044134
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$8.7万
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财政年份:1994
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负责人:IKEDA Hiroshi
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依托单位:
An effective teaching method aided by computer technology for the large classroom teaching
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项目类别:Grant-in-Aid for General Scientific Research (B)
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负责人:IKEDA Hiroshi
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依托单位:
海外基金