Tissue engineering based on reversible modification of bio-oriented scaffolds

在这项研究中，我开发了一种方法，通过使用一种可以一旦结合但对光做出反应而裂解的分子，对生物导向支架的表面属性进行可逆修饰。作为概念验证，我演示了用聚乙二醇可逆地修饰端氨基表面并控制其细胞粘附性。此外，基于类似的策略，我还成功地控制了生物胺的活性，并在金纳米颗粒和衬底上形成了表面化学梯度。

In this study, I have developed a method for reversible modification of the surface properties of bio-oriented scaffolds by using a molecule that can be once conjugated but cleaved in response to light. As a proof of concept, I demonstrated a reversible modification of an amino-terminated surface with poly(ethylene glycol) and control of its cell adhesiveness. In addition, I have succeeded in the control of the activity of biological amine and the formation of surface chemical gradients on gold nanoparticles and substrates based on the similar strategy.