Elucidation of new molecular basis for prevention of obesity through the systems of nutritional sensor

通过营养传感器系统阐明预防肥胖的新分子基础

• 批准号: 20700555
• 负责人: ARAI Hidekazu
• 金额: $ 2.83万
• 依托单位: University of Shizuoka
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20700555/
• 关键词: 生活習慣病; キシリトール; 高脂肪食; 内臓脂肪蓄積; 褐色脂肪; 熱産生

Here we investigated the effects of dietary xylitol on lipid metabolism and visceral fat accumulation in rats fed a high-fat diet. Visceral fat mass and plasma lipid concentrations were significantly lower in xylitol-fed rats than those in HFD rats. Gene expression levels of PPARγ, adiponectin and lipolysis enzymes in the adipose tissue of rats in the xylitol group were significantly higher. Furthermore, the expression levels of fatty acid oxidation-related genes in the liver of xylitol-fed rats were significantly higher than those of HFD rats. In conclusion, intake of xylitol may be beneficial in preventing the development of obesity and metabolic abnormalities. However, the mechanism of prevention for the fat accumulation by the xylitol intake is unknown.

在这里，我们研究了木糖醇对高脂饮食大鼠脂质代谢和内脏脂肪蓄积的影响。内脏脂肪量和血浆脂质浓度显着低于木糖醇喂养的大鼠比HFD大鼠。木糖醇组大鼠脂肪组织中PPARγ、脂联素和脂解酶基因表达水平显著升高。此外，脂肪酸氧化相关基因在木糖醇喂养大鼠的肝脏中的表达水平显着高于HFD大鼠。总之，木糖醇的摄入可能有利于预防肥胖和代谢异常的发展。然而，木糖醇摄入预防脂肪堆积的机制尚不清楚。

项目成果

健常者の代謝変化を反映する指標および要因の検討

反映健康个体代谢变化的指标和因素的检查

• 发表时间: 2010
• 作者: Hiasa Y;Kuzuhara H;Tokumoto Y;Konishi I;Onji M;et al.;Sato K;佐久間理英
• 通讯作者: 佐久間理英

Immprovement of glucose metabolism in patients with impaired glucose tolerance or diabetes by long-term administration of a palatinose-based liquid formula as apart of breakfast.

通过长期服用帕拉金糖液体配方奶粉作为早餐，改善糖耐量受损或糖尿病患者的葡萄糖代谢。

• 发表时间: 2009
• 期刊: J Clin Biochem Untr. 45(2)
• 作者: Konishi I;Hiasa Y;Shigematsu S;Hirooka M;Furukawa S;Abe M;Matsuura B;Michitaka K;Horiike N;Onji M;Sakuma M
• 通讯作者: Sakuma M

Effects of Long-term Intake of Xylitol on Visceral Fat Accumulation in Rats Fed High Fat Diet

长期摄入木糖醇对高脂饮食大鼠内脏脂肪堆积的影响

• 发表时间: 2008
• 作者: 小西一郎;日浅陽一;恩地森一;Arai H
• 通讯作者: Arai H

Palatinose and oleic acid act together to prevent pancreatic islet disruption in nondiabetic obese Zucker rats

• DOI: 10.2152/jmi.55.183
• 发表时间: 2008-08-01
• 期刊: JOURNAL OF MEDICAL INVESTIGATION
• 影响因子: 0.7
• 作者: Sato, Kazusa;Arai, Hidekazu;Takeda, Eiji
• 通讯作者: Takeda, Eiji

Hypocaloric high-protein diet improves fatty liver and hypertriglyceridemia in sucrose-fed obese rats via two pathways

• DOI: 10.1152/ajpendo.00014.2009
• 发表时间: 2009-07-01
• 期刊: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
• 影响因子: 5.1
• 作者: Uebanso, Takashi;Taketani, Yutaka;Takeda, Eiji
• 通讯作者: Takeda, Eiji