Elucidation of the molecular mechanism of the functional carbohydrate on the postprandial metabolic change

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The postprandial hyperglycemia is associated with onset of metabolic syndrome greatly, and palatinose which is an isomer of the sucrose, was identified that it is the nourishment which can reduce hyperglycemia after a meal. However, the molecular mechanisms and substrate availability of palatinose ingestion are not clear. For the measurement of metabolic flexibility after the carbohydrate load test, the pattern of the metabolic response and the gene expression in the liver accorded with a slower blood glucose rising. This study suggested that exchange of sucrose for palatinose might results in a more favorable metabolic response, and might help to reduce disease such as diabetes mellitus.