Development of ultra high-sensitive metabolomics utilizing F-trap derivatization and its application to assessment of pharmacotherapeutic effects

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We have developed a F-trap fluorescence derivatization method which enables ultra-sensitive and comprehensive analysis of endogenous amino metabolites. By combining this method and statistical technique, we established an assessment method of pharmacotherapeutic effects of anticancer drugs on tumor cells. Furthermore, we have also developed a fluorous scavenging derivatization (FSD) method which enables ultra-sensitive and comprehensive analysis of organic acid metabolites.