Elucidation of eruption mechanisms of teeth by bone resorption of alveolar bone

本研究采用肌醇1,4,5-三磷酸受体（IP_3Rs）拮抗剂xestospongin-C （XSC）检测其对破骨细胞的影响，进一步分析其与IP_3R型（IP_3R-III）破骨细胞粘附的关系。在XSC存在下，破骨细胞收缩，IP_3R-III与足小体共存减少，证实破骨细胞粘附面积。这表明IP_3R-III在足小体肌动蛋白细胞骨架的调节中起关键作用。

In this study the influence on the osteoclasts was examined by using the inositol 1,4,5-trisphosphate receptors (IP_3Rs) antagonist xestospongin-C (XSC) to do further analysis of the relation with the cellular adhesion in the osteoclasts of IP_3R type III (IP_3R-III). In the presence of XSC, shrinkage of osteoclasts and a decrease in the coexistence of IP_3R-III and podosomes, the adhesion area of osteoclasts were verified. It can be suggested that IP_3R-III accomplishes a key role in the adjustment of the actin cytoskeleton in podosomes.