The mechanism of exercise-induced increase in insulin sensitivity : Effect of exercise on NR4A receptor gene expression

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Exercise increases insulin sensitivity of glucose transport in skeletal muscle. Our study aimed to examine the possibility that exercise-induced increase in insulin sensitivity is mediated by the increased expression of NR4A receptors in skeletal muscle. However, this possibility is unlikely since exercise increased NR4A mRNA but not protein expression in rat skeletal muscle. On the other hand, our study showed that hindlimb immobilization decreased NR4A protein expression in rat postural muscle, suggesting the possibility that inactivity-induced insulin resistance is mediated by the reduced expression of NR4A receptors.