Satellite cell activation to the change of muscle fiber size and the effects of motor nerve innervations and aging

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Analyses were performed on the fiber phenotype expression, satellite cell activation, and the effects of heat stress at an early stage of rat soleus fiber regeneration. In heat stressed soleus regenerating fibers, slow type fiber containing only the slow myosin heavy chain isoform and enhanced activation of satellite cells were observed. These results suggest the possibility that heat stress accelerates the shift of fiber phenotype from fast to slow at an early stage of soleus fiber regenerating process.