Induction of ovalbumin-specific allergic reaction by ingestion of food additives including aluminum

摄入铝等食品添加剂可诱发卵清蛋白特异性过敏反应

• 批准号: 21500796
• 负责人: WAKABAYASHI Ayako
• 金额: $ 2.33万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21500796/
• 关键词: 健康と食生活; 食品衛生; 食品添加物; みょうばん; アルミニウム; 食物アレルギー; 樹状細胞; CD80; CD86; MHCクラスII分子; 卵白アルブミン; IgG1; IgG2a; T細胞増殖反応; IgE

In this study, we investigated whether the ingestion of aluminum potassium sulfate(APS) in food additives is involved in the triggering and development of allergies. Our research was conducted through animal experimentation and surveys. Oral administration of APS activated dendritic cells in the mesenteric lymph nodes in mice. Furthermore, production of ovalbumin(OVA)-specific antibodies and T cell proliferative responses were enhanced by oral administration of OVA and APS. We also showed that women with allergies consume foods with APS more frequently than woman without allergies. Thus, it was demonstrated that ingestion of APS enhanced immune responses and may contribute to the triggering and development of allergic reactions in mice and humans.

在本研究中，我们调查了食用食品添加剂中的硫酸铝钾（APS）是否参与过敏的触发和发展。我们的研究是通过动物实验和调查进行的。口服APS可激活小鼠肠系膜淋巴结中的树突状细胞。此外，口服OVA和APS可增强卵白蛋白（OVA）特异性抗体的产生和T细胞增殖反应。我们还发现，过敏的女性比没有过敏的女性更频繁地食用含有APS的食物。因此，研究表明，摄入APS可增强免疫反应，并可能促进小鼠和人类过敏反应的触发和发展。

项目成果

Induction of tumor-specific acquired immunity against already established tumors by selective activation of innate DEC-205^+dendritic cells

通过选择性激活先天 DEC-205^ 树突状细胞，诱导针对已形成肿瘤的肿瘤特异性获得性免疫

• 发表时间: 2010
• 作者: Date T;Moriya K;Wakabayashi A;Takahashi H
• 通讯作者: Takahashi H

Development of Antitumor Immunity by Oral Vaccination with Tumor Antigen and Cholera Toxin

口服肿瘤抗原和霍乱毒素疫苗增强抗肿瘤免疫力

• DOI: 10.1272/jnms.77.50
• 发表时间: 2010
• 期刊: Journal of Nippon Medical School
• 影响因子: 1
• 作者: Ayako Wakabayashi;Yoko Nakagawa;Masumi Shimizu;Hidemi Takahashi
• 通讯作者: Hidemi Takahashi

エイズウイルス外被糖蛋白特異的CD8陽性細胞障害性T細胞の遊離エピトープペプチドによるin vivoでのアポトーシス誘導とその制御

艾滋病病毒外壳糖蛋白特异性CD8阳性细胞毒性T细胞的游离表位肽在体内诱导和控制细胞凋亡

• 发表时间: 2011
• 作者: 中川洋子;清水真澄;野呂瀬嘉彦;若林あや子;高橋めぐみ;高橋秀実
• 通讯作者: 高橋秀実

経口ワクチンによる抗腫瘍免疫誘導法の開発

口服疫苗抗肿瘤免疫诱导方法的开发

• 发表时间: 2009
• 作者: Wakabayashi A;Moriya K;Harimoto H;Tomita Y;Shimizu M;Takahashi H;Wakabayashi Ayako;若林あや子
• 通讯作者: 若林あや子

Induction of tumor-specific acquired immunity against already established tumors by selective stimulation of innate DEC-205(+) dendritic cells.

通过选择性刺激先天DEC-205（+）树突状细胞，诱导肿瘤特异性获得的免疫力对已经建立的肿瘤。

• DOI: 10.1007/s00262-010-0835-z
• 发表时间: 2010-07
• 期刊: CANCER IMMUNOLOGY IMMUNOTHERAPY
• 影响因子: 5.8
• 作者: Moriya, Keiichi;Wakabayashi, Ayako;Shimizu, Masumi;Tamura, Hideto;Dan, Kazuo;Takahashi, Hidemi
• 通讯作者: Takahashi, Hidemi