Analysis of the bioactive substances contained in the lactic acid bacteria-metabolic products from soybean milk

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PS-B1 is fermented products cultivated from soybean milk using lactic acid bacteria. We found that PS-B1 inhibited significantly the growth of human leukemia HL-60 cells by the induction of apoptosis and the increase of the intracellular reactive oxygen species was important for apoptosis. In the experiments using the alcoholic injury liver model constructed by using rat hepatocytes and hepatic stellate cells, PS-B1 inhibited the necrosis of hepatocytes and suppressed the production of the collagen in hepatic stellate cells. PS-B1 also indicated the liver preservation action against the viral and drug-induced injury liver model.