Elucidation of natural products to regulate glucose-transporters on the small intestine

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Through exploratory study of the food material to suppress postprandial elevation of blood glucose level in mice, this study aimed to find and identified compounds having inhibitory effect of glucose absorption from the intestinal tract. As a result, some inhibitors against carbohydrate digestive enzymes or against glucose-transport in the intestine were purified with chromatography and then identified by spectral analysis. Multiflorin A, which was obtained from peach leaf extract, showed the most powerful effect compared with known transporter-inhibitors. Then the study of structure-activity relationship showed that its acetyl group is important to express the activity in vivo.