Method Development for Assessing the Progression of Metabolic Syndrome by Multiplex-dynamic Analysis of Compounds of Biological Importance

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The multiplex analytical methods for determining compounds of biological importance were developed to examine the progression of metabolic syndrome. Dynamic analyses of plasma free fatty acids, cholesterol, and pathologically important sterols in animal model of disease were performed by sensitive and precise HPLC with electrochemical detection. Moreover, a novel analytical strategy based on statistics aspect was shown to be applicable to examine the interaction between free fatty acids and blood glucose level. It was concluded that the present methods were useful various kinetic studies in clinical fields.