Fabrication of anodized titanium artificial bone induced osteoblast cells

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Micrometer-scale patterning-TiO_2 films derived by sol-gel method were formed on a titanium plate using by photo-irradiation patterning method. The patterned TiO_2 gel film onto titanium was then anodized at constant current density with DC or pulsed-current density by anodic oxidation in an HAp-containing alkaline bath under spark discharge, to follow preparing various pore shapes on patterned-TiO_2 film. Moreover, reversed patterning-film was also prepared by the combination of photosensitizing and anodizing method except etching process. The bioactivity, which was investigated by cell culture examination, was drastically improved for HAp-loaded titania film in comparison with anodized titanium film without HAp.