Role of novel kinases that regulate the function of phospholipid flippases
Role of novel kinases that regulate the function of phospholipid flippases
批准号:
21570192
负责人:
YAMAMOTO Takaharu
金额:
$3.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
我们的酵母遗传筛选成功地鉴定出α抑制蛋白Art5是一种新的DNF1/2磷脂翻转酶调节因子。我们发现Art5可能通过与Dnf1/2的结合来调节生物膜的磷脂不对称。此外,我们开发了一种新的方法来分析PHOT激酶的功能,通过在活的酵母系统中生产它们来分析酵母Fpk1/2翻转酶的植物同源物。
英文摘要
Our yeast genetic screening successfully identified Art5, one of α-arrestins, as a novel regulator of Dnf1/2 phospholipid flippases. We found that Art5 may condition phospholipid asymmetry of biomembranes, mediated by its binding with Dnf1/2. In addition, we developed a novel method to analyze functions of PHOT kinases, plant homologues of yeast Fpk1/2 flippase kinases, by producing them in the living yeast system.
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Mutations in the N-terminal flanking region of the blue-light sensing domain LOV2 disrupt its repressive activity on the kinase domain in the Chlamydomonas phototropin
蓝光传感结构域 LOV2 N 端侧翼区域的突变破坏了其对衣藻向光素激酶结构域的抑制活性
DOI:
--
发表时间:
2012
期刊:
J Biol Chem.
影响因子:
--
作者:
[Aihara Y, Yamamoto T, Okajima K, Yamamoto K, Suzuki T, Tokutomi S, Tanaka K, Nagatani A]
通讯作者:
Nagatani A
Roles of phospholipid flippases and their related ArfGAP for protein trafficking
磷脂翻转酶及其相关 ArfGAP 在蛋白质运输中的作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[武田美代子, 山本隆晴, 田中一馬, 加藤尚志, 加藤尚志, 山本隆晴]
通讯作者:
山本隆晴
DOI:
10.1093/jb/mvq140
发表时间:
2011-02
期刊:
Journal of biochemistry
影响因子:
2.7
作者:
[Kazuma Tanaka;K. Fujimura‐Kamada;Takaharu G. Yamamoto]
通讯作者:
Kazuma Tanaka;K. Fujimura‐Kamada;Takaharu G. Yamamoto
膜輸送におけるリン脂質フリッパーゼの役割
磷脂翻转酶在膜运输中的作用
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ohashi, K., Fujiwara, S., Watanabe, T., Kondo, H., Kiuchi, T., Sato, M., and Mizuno, K., 山本隆晴,鎌田このみ,田中一馬]
通讯作者:
山本隆晴,鎌田このみ,田中一馬
DOI:
10.1091/mbc.e09-05-0412
发表时间:
2010-04-01
期刊:
Molecular biology of the cell
影响因子:
3.3
作者:
[Yamamoto T, Mochida J, Kadota J, Takeda M, Bi E, Tanaka K]
通讯作者:
Tanaka K
共 13 条
Functional analysis of histones during sexual reproduction
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批准号:15K18538
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.83万
-
财政年份:2015
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负责人:YAMAMOTO Takaharu
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依托单位:
A Fundamental Study on Educational Scaffolding for Development Reading Literacy
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批准号:21530939
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.0万
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财政年份:2009
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负责人:YAMAMOTO Takaharu
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依托单位:
A Fundamental Study on the Role of Group Discussions in Teaching of Reading
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批准号:16530593
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.15万
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财政年份:2004
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负责人:YAMAMOTO Takaharu
-
依托单位: