I dentification and characterization of the genes involved in generation or quenching of reactive oxygen species

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Oxygen is essential for aerobic organisms, but generates reactive oxygen species(ROS), which can cause cellular dysfunction that would accelerate aging and diseases. We have studied the genes involved in the generation or the quenching of ROS with use of the nematode Caenorhabditis elegans as a model organism. In this study, we analyzed the expression patterns of OXY-5 and RAD-8 in C. elegans, and identified genes that, when down regulated, cause an increased sensitivity to ROS by systematic screening of the genes located on linkage group I.