Elucidation of functionality of equol-producing bacteria

雌马酚是大豆苷元的代谢产物，由肠道中的肠道植物群产生。雌马酚对生活方式疾病的预防作用已被人们所期待。本研究通过雌马酚产生菌与雌三醇、雌酮和β-雌二醇的体外厌氧培养，首次阐明了雌马酚产生菌能强烈地将雌酮转化为β-雌二醇。给喂食0.05%大豆黄酮-10%猪油饲料的小鼠施用牛尿酚产生菌影响脂质代谢和粪便胆汁酸浓度。雌马酚产生菌组小鼠尿中β-雌二醇含量显著低于生理盐水组。

Equol is a metabolite of daidzein that is produced by the intestinal flora in the gut. Life style disease prevention of equol has been expected. In our research, In in vitro anaerobic incubation of equol-producing bacteria with estriol, estrone, andβ-estradiol, we firstly elucidated that equol-producing bacteria strongly converted estrone toβ-estradiol. Administration of equol-producing bacteria to mice fed the 0.05%-daidzein-10% lard diet affected the lipid metabolism and fecal bile acid concentration. The urinary amounts ofβ-estradiol were significantly lower in the mice administrated of equol-producing bacteria than in the mice administrated of physiological saline.