Glycomic approaches for the identification of tumor-associated glycoproteins as potential tumor markers

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Previously we suggested that heterogeneous nuclear ribonucleoproteins(hnRNPs) could be carrier proteins of sialyl Lewis x(sLe^x) glycoepitope which is widely used as a tumor marker. In this study we demonstrated that some hnRNPs were co-localized with sLe^x in Golgi apparatus, and their levels were up-regulated during S/G2 phases of the cell cycles. Furthermore, we found that expression of sLe^x was up-regulated by Fuc-T VI, and inhibition of Fuc-T VI expression suppressed the proliferation of colorectal cancer cell lines. These results suggested that sLe^x and hnRNP might be associated with the proliferation of colorectal cells and some hnRNPs could be used as novel tumor makers.