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Induction mechanism of imposex in marine gastropods by retinoids

类维生素A诱导海洋腹足动物强行性的机制

基本信息

批准号：
21590143
负责人：
NISHIKAWA Jun-ichi
金额：
$ 2.83万
依托单位：
Mukogawa Women's University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

项目摘要

Organotin compounds have been widely used as antifouling pints for ships and fishing nets since the 1960s and have thus released into marine environments. Aquatic invertebrates, particularly marine gastropods, are extremely sensitive to organotin compounds such as tributyltin(TBT) and triphenyltin(TPT). So far, very low-concentartion of TBT or TPT have been shown to induce imposex(superimposition of male genitalia on female) in marine gastropods. Although the inposex induction mechanism has been controversial for many years, we have reported that TBT and TPT are potent and efficacious activators of retinoid X receptor(RXR), and the natural ligand of RXR, 9-cis retinoic acid, induces imposex. However, in vertebrates, all-trans retinoic acid is well-known morphogen important for axial patterning and organ formation in early development. In this study, we analyze the molluscan receptor for all-trans retinoic acid in the view of the evolutionary history of retinoid machinery.

自20世纪60年代以来，有机锡化合物被广泛用作船舶和渔网的防污品脱，并因此释放到海洋环境中。水生无脊椎动物，特别是海洋腹足动物，对三丁基锡(TBT)和三苯基锡(TPT)等有机锡化合物非常敏感。到目前为止，极低浓度的TBT或TPT已被证明会在海洋腹足动物中诱发性畸变(雄性生殖器叠加在雌性身上)。虽然性畸变的诱导机制多年来一直存在争议，但我们已报道TBT和TPT是维甲酸X受体(RXR)的强效激活剂，而RXR的天然配体9-顺式维甲酸可诱导性反转。然而，在脊椎动物中，全反式维甲酸是众所周知的形态因子，对轴向模式和早期发育的器官形成非常重要。在这项研究中，我们从维甲酸机制的进化史的角度分析了软体动物对全反式维甲酸的受体。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Effect of Lipopolysaccharide on the Xenobiotic-Induced Expression and Activity of Hepatic Cytochrome P450 in Mice

DOI：
10.1248/bpb.35.473
发表时间：
2012-04-01
期刊：
BIOLOGICAL & PHARMACEUTICAL BULLETIN
影响因子：
2
作者：
Moriya, Nozomu;Kataoka, Hiromi;Kugawa, Fumihiko
通讯作者：
Kugawa, Fumihiko

Contamination with retinoic acid receptor agonists in two rivers in the Kinki region of Japan.

DOI：
10.1016/j.watres.2010.01.005
发表时间：
2010-04
期刊：
Water research
影响因子：
12.8
作者：
D. Inoue;Koki Nakama;K. Sawada;Taro Watanabe;Mai Takagi;K. Sei;Min Yang;J. Hirotsuji;Jianying Hu;J. Nishikawa;T. Nakanishi;M. Ike
通讯作者：
D. Inoue;Koki Nakama;K. Sawada;Taro Watanabe;Mai Takagi;K. Sei;Min Yang;J. Hirotsuji;Jianying Hu;J. Nishikawa;T. Nakanishi;M. Ike

Identification of retinoic acid receptor agonists in sewage treatment plants.

DOI：
10.1021/es9000328
发表时间：
2009-09
期刊：
Environmental science & technology
影响因子：
11.4
作者：
Huajun Zhen;Xiaoqin Wu;Jianying Hu;Yang Xiao;Min Yang;J. Hirotsuji;J. Nishikawa;T. Nakanishi
通讯作者：
Huajun Zhen;Xiaoqin Wu;Jianying Hu;Yang Xiao;Min Yang;J. Hirotsuji;J. Nishikawa;T. Nakanishi

Site-directed mutagenesis of rat thioltransferase : effect of essential cysteine residues for protection against oxidative stress.

大鼠硫醇转移酶的定点诱变：必需半胱氨酸残基对氧化应激的保护作用。