Improvement of inflammatory bowel diseases based on expression and functional changes of P-glycoprotein by methylpredonislone and essential fatty acids

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Linoleic acid(LA) and.-linolenic acid(α-LnA) decrease the absorption of methylpredonisolone(MP) from small intestine in inflammatory bowel disease(IBD) model rats and have delivery effects to large intestine to MP. LA and α-LnA have anti-inflammatory effects and regulatory effects on expression and function of P-glycoprotein(P-gp) in intestinal epithelial cells. It suggests that administration of these essential unsaturated fatty acids not only prevent progress of IBD and also normalize intestinal absorption and disposition of the drug which is a substrate of P-gp in vivo. More experimental information and data are necessary for more efficient administration schedule of drugs in IBD therapy.