Establishment of individualized dosage regimen based on pharmacodynamic model considering efficacy expression process of biological agents for rheumatoid arthritis

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Based on pharmacodynamic model for pharmacotherapy of rheumatoid arthritis, it was thought that the effect of infliximab appeared comparatively early, although its variation was large. In contrast, the effects of adalimumab and etanerscept appeared slowly, whereas these were stably. Regarding the individual variation, the level of TNFα by the influence of single nucleotide polymorphisms(SNPs) in TNFα gene was different. It was considered that dosage regimen of each drug for individual patient can be established with the developed model in view of the individual quantitative factor of TNFα.