Targeted therapy for anti-cancer drug resistance mediated by several kinase pathways activation

多种激酶通路激活介导的抗癌耐药的靶向治疗

• 批准号: 21590180
• 负责人: KOBAYASHI Hiroyuki
• 金额: $ 2.91万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590180/
• 关键词: 癌; 薬剤反応性; 酵素; シグナル伝達; 核酸

Idarubicin is one of the standard treatments for patients with acute myeloid leukemia. We have developed human acute leukemia cell line resistant to idarubucin. Several kinase pathways were activated in the resistant cell line. Small interfering RNA-mediated gene silencing of the activated kinases resulted in the partial reversal of drug resistance. The magnitude of reversal depended on the effectiveness of gene silencing. The resistance for idarubucin was also partially overcome by means of molecular targeted drugs or inhibitors that inhibit the activated kinases. The magnitude of reversal depended on the effectiveness of kinase inhibition.

艾达鲁肽是急性髓性白血病患者的标准治疗方法之一。我们已经建立了人急性白血病细胞株耐依达芦。在耐药细胞系中有几条激酶途径被激活。小干扰RNA介导的激活激酶的基因沉默导致耐药性的部分逆转。逆转的幅度取决于基因沉默的有效性。通过分子靶向药物或抑制活化激酶的抑制剂，也部分克服了对伊达比星的耐药性。逆转的幅度取决于激酶抑制的有效性。

项目成果

Significant relationship between platelet activation and apnea-hypopnea index in patients with obstructive sleep apnea syndrome

阻塞性睡眠呼吸暂停综合征患者血小板活化与呼吸暂停低通气指数之间的显着关系

• 发表时间: 2011
• 期刊: Tokai Journal of Experimental and clinical Medicine
• 作者: 山田晴生;ら;Kondo Y
• 通讯作者: Kondo Y

Dioxins in ascites and serum of women with endometriosis

子宫内膜异位症女性腹水和血清中的二恶英

• 发表时间: 2011
• 期刊: Human Reproduction
• 影响因子: 6.1
• 作者: Iida T;Ogawa S;Tamegai H;Adachi Y;Saito H;Ikegawa S;Konishi H;Takagi A;Matsuzaki T;L.Y.Cai
• 通讯作者: L.Y.Cai

One-Year Cardiovascular Event Rates in Japanese Outpatients With Myocardial Infarction, Stroke, and Atrial Fibrillation - Results From the Japan Thrombosis Registry for Atrial Fibrillation, Coronary, or Cerebrovascular Events (J-TRACE)

• DOI: 10.1253/circj.cj-11-0378
• 发表时间: 2011-11-01
• 期刊: CIRCULATION JOURNAL
• 影响因子: 3.3
• 作者: Goto, Shinya;Ikeda, Yasuo;Kobayashi, Hiroyuki
• 通讯作者: Kobayashi, Hiroyuki

Beneficial effects of medical advice provided to elderly persons under the anti-aging health check-up system at Tokai University Tokyo Hospital

东海大学东京医院抗衰老健康检查制度对老年人提供医疗咨询的效果

• 发表时间: 2009
• 期刊: Tokai J.Exp.Clin.Med. 34
• 作者: 松本紘典;高岡龍蔵;加藤美紀;鈴木智子;安藤義則;春名光昌;灘井雅行;Yasuhiro NISHIZAKI
• 通讯作者: Yasuhiro NISHIZAKI

Cysteinyl leukotriene receptor antagonists inhibit tumor metastasis by inhibiting capillary permeability.

• DOI: 10.2302/kjm.59.10
• 发表时间: 2010
• 期刊: The Keio journal of medicine
• 作者: Nozaki M;Yoshikawa M;Ishitani K;Kobayashi H;Houkin K;Imai K;Ito Y;Muraki T
• 通讯作者: Muraki T