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Targeted therapy for anti-cancer drug resistance mediated by several kinase pathways activation

Targeted therapy for anti-cancer drug resistance mediated by several kinase pathways activation
多种激酶通路激活介导的抗癌耐药的靶向治疗
批准号：
21590180
负责人：
KOBAYASHI Hiroyuki
金额：
$2.91万
依托单位：
Tokai University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009 至 2011
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590180/
关键词：
癌薬剤反応性酵素シグナル伝達核酸

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中文摘要
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英文摘要
Idarubicin is one of the standard treatments for patients with acute myeloid leukemia. We have developed human acute leukemia cell line resistant to idarubucin. Several kinase pathways were activated in the resistant cell line. Small interfering RNA-mediated gene silencing of the activated kinases resulted in the partial reversal of drug resistance. The magnitude of reversal depended on the effectiveness of gene silencing. The resistance for idarubucin was also partially overcome by means of molecular targeted drugs or inhibitors that inhibit the activated kinases. The magnitude of reversal depended on the effectiveness of kinase inhibition.
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Significant relationship between platelet activation and apnea-hypopnea index in patients with obstructive sleep apnea syndrome
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DOI： --
发表时间： 2011
期刊： Tokai Journal of Experimental and clinical Medicine
影响因子： --
作者： [山田晴生, ら, Kondo Y]
通讯作者： Kondo Y
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子宫内膜异位症女性腹水和血清中的二恶英
DOI： --
发表时间： 2011
期刊： Human Reproduction
影响因子： 6.1
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One-Year Cardiovascular Event Rates in Japanese Outpatients With Myocardial Infarction, Stroke, and Atrial Fibrillation - Results From the Japan Thrombosis Registry for Atrial Fibrillation, Coronary, or Cerebrovascular Events (J-TRACE)
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发表时间： 2011-11-01
期刊： CIRCULATION JOURNAL
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通讯作者： Kobayashi, Hiroyuki
Beneficial effects of medical advice provided to elderly persons under the anti-aging health check-up system at Tokai University Tokyo Hospital
东海大学东京医院抗衰老健康检查制度对老年人提供医疗咨询的效果
DOI： --
发表时间： 2009
期刊： Tokai J.Exp.Clin.Med. 34
影响因子： --
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通讯作者： Yasuhiro NISHIZAKI
共 6 条
    Candidate biomarkers for predicting drug response in cancer treatment
    • 批准号：
      15K08109
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $3.16万
    • 财政年份：
      2015
    • 负责人：
      KOBAYASHI Hiroyuki
    • 依托单位：
      Tokai University
    Effects of social stress on emotional disorders and effects of the Traditonal Kampo medicine
    • 批准号：
      15K01662
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $2.41万
    • 财政年份：
      2015
    • 负责人：
      KOBAYASHI Hiroyuki
    • 依托单位：
      Juntendo University
    Memory Structure of Texture Feeling and Its Emotional Effects
    • 批准号：
      24500254
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $3.24万
    • 财政年份：
      2012
    • 负责人：
      KOBAYASHI Hiroyuki
    • 依托单位：
      Chiba University
    Targeted therapy for anti-cancer drug resistance: Basic research
    • 批准号：
      24590214
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $3.41万
    • 财政年份：
      2012
    • 负责人：
      KOBAYASHI Hiroyuki
    • 依托单位：
      Tokai University
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