Clarifying the regulatory mechanism of insulin signal in septicemia

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We analyzed the insulin signal in septicemia, using the brain and lung tissue in septic model mice. Until the certain period, insulin signal was increased by some defensive mechanisms. However, the signal was reduced gradually, and the degree of tissue damage was increased. Meanwhile, treatment the drugs which maintain the signal reduced the tissue damage. It was expected that the damage in septicemia would be reduced, if we use the protective system via insulin signal, which reduce the oxidative and nitrative stress.