Studies on molecular basis for regulation of beta-oxidation system
Studies on molecular basis for regulation of beta-oxidation system
批准号:
21590314
负责人:
HOMMA Yoshimi
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
特发性肺纤维化患者肺成纤维细胞线粒体中VLCAD1磷酸化水平降低。PKA磷酸化VLCAD1的Ser-586位点,其磷酸化缺陷突变体增强了自由基氧的产生。这表明β氧化系统受包括PKA在内的线粒体内信号系统的调控。
英文摘要
Phosphorylation level of VLCAD1 decreased in mitochondria of lung fibroblasts established from patients with idiopathic pulmonary lung fibrosis. PKA phosphorylated VLCAD1 at Ser-586, and its phosphorylation-defective mutant enhanced production of radical oxygen species. These suggest that beta oxidation system is regulated by intra-mitochondrial signaling system including PKA.
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DOI:
10.1161/atvbaha.110.203083
发表时间:
2010-10
期刊:
Arteriosclerosis, Thrombosis, and Vascular Biology
影响因子:
--
作者:
[Reiichi Murakami;T. Osanai;H. Tomita;Satoko Sasaki;Atsushi Maruyama;K. Itoh;Y. Homma;K. Okumura]
通讯作者:
Reiichi Murakami;T. Osanai;H. Tomita;Satoko Sasaki;Atsushi Maruyama;K. Itoh;Y. Homma;K. Okumura
Reguratory mechanism of oxidative phosphorylation by mitochondrial c-Src
线粒体c-Src氧化磷酸化的调节机制
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ogura M, Yamaki J, Homma MK, Homma Y]
通讯作者:
Homma Y
肺線維芽細胞のプロテオミクス解析
肺成纤维细胞的蛋白质组学分析
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[鈴木俊幸, ら]
通讯作者:
ら
DOI:
10.1152/ajpcell.00231.2009
发表时间:
2010-01-01
期刊:
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
影响因子:
5.5
作者:
[Kabuyama, Yukihito, Suzuki, Toshiyuki, Homma, Yoshimi]
通讯作者:
Homma, Yoshimi
Coronary vasospasm induced in transgenic mouse with the increased phospholipase C-δ1 activity
磷脂酶 C-δ1 活性增加的转基因小鼠诱导冠状动脉痉挛
DOI:
--
发表时间:
2012
期刊:
Circulation
影响因子:
37.8
作者:
[Shibutani S, et al]
通讯作者:
et al
共 10 条
Analysis of DNA methylation pattern of promoter CpG islands in idiopathic pulmonary fibrosis.
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批准号:15390257
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.54万
-
财政年份:2003
-
负责人:HOMMA Yoshimi
-
依托单位:
Cooperative study on molecular mechanism of GFAP expression.
-
批准号:10044307
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.64万
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财政年份:1998
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负责人:HOMMA Yoshimi
-
依托单位:
Studies on ontogenic significance of PLC signaling systems.
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批准号:10480172
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.36万
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财政年份:1998
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负责人:HOMMA Yoshimi
-
依托单位:
Identification and functional analysis of proteins involved in novel pathway for PLC activation.
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批准号:08458184
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.16万
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财政年份:1996
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负责人:HOMMA Yoshimi
-
依托单位:
Trials for development of novel inhibitors for intracellular signaling.
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批准号:06558095
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$6.27万
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财政年份:1994
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负责人:HOMMA Yoshimi
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依托单位:
海外基金