Elucidation of the function of Aurora kinases in mitosis and itsdysregulation in cancer
Elucidation of the function of Aurora kinases in mitosis and itsdysregulation in cancer
阐明极光激酶在有丝分裂中的功能及其在癌症中的失调
批准号：
21590331
负责人：
KIMURA Masashi
金额：
$3.08万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009 至 2012
中文摘要
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英文摘要
Our study using Aurora inhibitor indicate that Aurora is essentialfor cell division and survival. Several proteins, which are regulated by Aurora kinases,play important roles in mitosis. RNA interference of centrosomal proteins includingAurora A induced cell death, which depended on the checkpoint proteins. The expressionof Aurora A and Plk1 were upregulated in cancer cells, but those of the enzymes whichdegrade them were downregulated.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
DOI：
10.2174/156800912801784839
发表时间：
2012-06
期刊：
Current cancer drug targets
影响因子：
3
作者：
[A. Matsuhashi;T. Ohno;M. Kimura;A. Hara;M. Saio;A. Nagano;G. Kawai;M. Saitou;I. Takigami;K. Yamada;Y. Okano;K. Shimizu]
通讯作者：
A. Matsuhashi;T. Ohno;M. Kimura;A. Hara;M. Saio;A. Nagano;G. Kawai;M. Saitou;I. Takigami;K. Yamada;Y. Okano;K. Shimizu
DOI：
10.3892/or_00000552
发表时间：
2009-11-01
期刊：
ONCOLOGY REPORTS
影响因子：
4.2
作者：
[Baba, Seiji, Hara, Akira, Shibata, Toshiyuki]
通讯作者：
Shibata, Toshiyuki
DOI：
10.1016/j.bbrc.2011.05.104
发表时间：
2011-06
期刊：
Biochemical and biophysical research communications
影响因子：
3.1
作者：
[Takashi Yoshioka;M. Kimura;M. Saio;S. Era;Y. Okano]
通讯作者：
Takashi Yoshioka;M. Kimura;M. Saio;S. Era;Y. Okano
Development of scientific education content to visualize the history of 4 billion years of life.
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批准号：15K00990
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项目类别：Grant-in-Aid for Scientific Research (C)
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资助金额：$3.0万
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财政年份：2015
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负责人：KIMURA Masashi
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依托单位：
Educational Research for amalgamate with Science and Art to activate the Science Communication
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批准号：17500604
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项目类别：Grant-in-Aid for Scientific Research (C)
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资助金额：$2.23万
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财政年份：2005
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负责人：KIMURA Masashi
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依托单位：
海外基金
