Elucidation of the function of Aurora kinases in mitosis and itsdysregulation in cancer

阐明极光激酶在有丝分裂中的功能及其在癌症中的失调

• 批准号: 21590331
• 负责人: KIMURA Masashi
• 金额: $ 3.08万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590331/
• 关键词: がん; オーロラキナーゼ; 細胞分裂; 細胞死; 転写制御

Our study using Aurora inhibitor indicate that Aurora is essentialfor cell division and survival. Several proteins, which are regulated by Aurora kinases,play important roles in mitosis. RNA interference of centrosomal proteins includingAurora A induced cell death, which depended on the checkpoint proteins. The expressionof Aurora A and Plk1 were upregulated in cancer cells, but those of the enzymes whichdegrade them were downregulated.

我们使用Aurora抑制剂的研究表明，Aurora对细胞分裂和存活至关重要。由极光激酶调控的几种蛋白质在有丝分裂中起重要作用。RNA干扰包括Aurora A在内的中心体蛋白可诱导细胞死亡，这依赖于检查点蛋白。Aurora A和Plk 1在癌细胞中的表达上调，但降解它们的酶的表达下调。

项目成果

Growth suppression and mitotic defect induced by JNJ-7706621, an inhibitor of cyclin-dependent kinases and aurora kinases.

• DOI: 10.2174/156800912801784839
• 发表时间: 2012-06
• 期刊: Current cancer drug targets
• 影响因子: 3
• 作者: A. Matsuhashi;T. Ohno;M. Kimura;A. Hara;M. Saio;A. Nagano;G. Kawai;M. Saitou;I. Takigami;K. Yamada;Y. Okano;K. Shimizu

Aberrant promoter hypermethylation of the CHFR gene in oral squamous cell carcinomas

• DOI: 10.3892/or_00000552
• 发表时间: 2009-11-01
• 期刊: ONCOLOGY REPORTS
• 影响因子: 4.2
• 作者: Baba, Seiji;Hara, Akira;Shibata, Toshiyuki
• 通讯作者: Shibata, Toshiyuki

Plk1 is negatively regulated by RNF8.

• DOI: 10.1016/j.bbrc.2011.05.104
• 发表时间: 2011-06
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: Takashi Yoshioka;M. Kimura;M. Saio;S. Era;Y. Okano