Regulation of ErbB signaling by N-glycan

点击翻译按钮获取中文摘要

The aim of this study is to understand the mechanisms by which N-glycan regulate function and structure of ErbB. We prepared the extracellular domain of ErbB(sErbB) and N418Q mutant of ErbB3. sErbB3 suppressed heregulin signaling more effectively than ErbB2 or ErbB4, and N418Q mutant suppressed more than wild type. Cell proliferation-inhibitory activity of sErbB3 was also upregulated by N418Q mutation. The results indicate that N-glycan on Asn418 of ErbB3 regulates the ErbB3 signaling.