Analysis of diabetes mellitus in mutant cryptochrome1 transgenic mice

我们先前的研究表明，带有半胱氨酸414突变的无处不在表达小鼠隐色素1(CRY1)的转基因小鼠不仅表现出异常的昼夜行为，而且还表现出糖尿病的症状。为了阐明糖尿病的发病机制，本研究检测了转基因小鼠这种疾病的年龄相关性特征，发现其症状类似于人类MODY(成熟型幼年糖尿病)。我们发现，小鼠从幼年起就表现出胰岛素基因以及几个与SS细胞功能有关的基因表达减少，这些基因可以导致类似于人类MODY的早发性糖尿病。

We previously showed that transgenic mice ubiquitously expressing mouse cryptochrome1 (CRY1) with a mutation in cysteine414 display not only anomalous circadian behavior but also symptoms of diabetes mellitus.In order to clarify yet uncovered pathogenesis of the diabetes, in this study we examined age-dependent characteristics of the disorder of the transgenic mice, and found that the symptom resemble human MODY (maturity onset diabetes mellitus of the young). We showed that the mice showed from young age reduced expression of insulin gene along with several genes whose expression is involved in the function of ss-cells, which can cause early-onset diabetes similar to human MODY.