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Pathogenesis of tissue remodeling caused by endogenous AGE and advanced targeting therapy

Pathogenesis of tissue remodeling caused by endogenous AGE and advanced targeting therapy
内源性AGE引起组织重塑的发病机制及先进靶向治疗
批准号:
21590604
负责人:
MORI Shuji
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
The protein array analysis with endogenous AGE as specific probe showed some high affinity binding factors for endogenous AGE, suggesting the formation of pathophysiological cluster in the local site of inflammatory. In addition, we succeeded the establishment of in vitro binding assay between recombinant endogenous AGE and RAGE. Also, Cell-based assay upon NF-kB activation and proinflammatory cytokine production was developed, providing the convenient platform for exploration of specific antagonist to endogenous AGE.
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DOI: 10.1124/jpet.109.160861
发表时间: 2010-03
期刊: Journal of Pharmacology and Experimental Therapeutics
影响因子: 3.5
作者: [Hideo Takahashi;Keyue Liu;H. Wake;S. Mori;Jiyong Zhang;Rui Liu;T. Yoshino;M. Nishibori]
通讯作者: Hideo Takahashi;Keyue Liu;H. Wake;S. Mori;Jiyong Zhang;Rui Liu;T. Yoshino;M. Nishibori
DOI: 10.1124/jpet.109.157594
发表时间: 2009-11
期刊: Journal of Pharmacology and Experimental Therapeutics
影响因子: 3.5
作者: [Hideo Takahashi;Keyue Liu;H. Wake;S. Mori;Jiyong Zhang;Rui Liu;T. Yoshino;M. Nishibori]
通讯作者: Hideo Takahashi;Keyue Liu;H. Wake;S. Mori;Jiyong Zhang;Rui Liu;T. Yoshino;M. Nishibori
DOI: 10.1161/atvbaha.110.218669
发表时间: 2011-02-01
期刊: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
影响因子: 8.7
作者: [Kanellakis, Peter, Agrotis, Alex, Bobik, Alex]
通讯作者: Bobik, Alex
アレイ解析によるHMGB1相互作用因子の網羅的探索
通过阵列分析全面搜索 HMGB1 相互作用因子
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [四釜佳子, 原悦子, 齋藤慶子, 杉本一博, 保嶋実, 森秀治]
通讯作者: 森秀治
11
    Study of the pathophysiological significance of endogenous AGE as an exacerbating factor for tissue remodeling, and the development of novel targeted therapy
    • 批准号:
      18K06807
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.75万
    • 财政年份:
      2018
    • 负责人:
      MORI Shuji
    • 依托单位:
    Roles of AGEs as exacerbation factor in pathogenesis of tissue remodeling and the development of novel targeted therapy
    • 批准号:
      15K08605
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.16万
    • 财政年份:
      2015
    • 负责人:
      MORI Shuji
    • 依托单位:
    Pathophysiological role of AGEs as exacerbation factor in tissue remodeling and molecular targeted therapy
    • 批准号:
      24590672
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.49万
    • 财政年份:
      2012
    • 负责人:
      MORI Shuji
    • 依托单位:
    Experimental study of perception-action systems in real, complexenvironments
    • 批准号:
      21330169
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.06万
    • 财政年份:
      2009
    • 负责人:
      MORI Shuji
    • 依托单位:
    海外基金