The study on the developmental neurotoxicity of organotin in rats by analyzing mRNA and protein expressions and behaviors

观察了三丁基锡（TBT）对F1代大鼠的神经毒性作用。妊娠大鼠通过食物接触三丁基锡化合物，因此，F1代大鼠通过胎盘和母鼠乳汁接触三丁基锡化合物。断奶后，一半的F1大鼠通过食物暴露于三丁基锡化合物。观察到通过胎盘和母鼠乳汁接触三丁基锡化合物的F1代大鼠的行为受到抑制，与对照组相比，体重也有所下降。与对照组相比，断奶后（3周龄）通过食物接触三丁基锡化合物的F1代大鼠的活动和体重也有所下降。断奶后立即接触三丁基锡化合物与通过胎盘和母奶接触三丁基锡化合物一样具有毒性。TBT对大鼠行为的抑制作用可能与多巴胺代谢有关，中脑酪氨酸羟化酶、多巴胺转运体和多巴胺受体D2表达下调。

The neurotoxic effects of tributyltin(TBT) on the F1 rats were examined. The pregnant rats were exposed to TBT via their food, therefore, the F1 rats were exposed to TBT via the placenta and their dam's milk. After weaning, the half of F1 rats were exposed to TBT via their food. The inhibitory effects of behaviors in the F1 rats exposed to TBT via the placenta and their dam's milk were observed as well as the decrease in their body weight compared to the control. The F1 rats exposed to TBT via their food after weaning(at 3 weeks of age) also showed lower activities and body weight compared to the control. The exposure to TBT just after the weaning is toxic as the exposure via the placenta and their dam's milk. The inhibitory effects on the behaviors by TBT may be related to dopamine metabolism, since tyrosine hydorxylase, dopamine transporter and dopamine receptor D2 in the midbrain were down-regulated.