The study on the developmental neurotoxicity of organotin in rats by analyzing mRNA and protein expressions and behaviors

研究了三丁基锡（TBT）对F1大鼠的神经毒性作用。怀孕大鼠通过食物接触TBT，因此F1大鼠通过胎盘和母鼠乳汁接触TBT。断奶后，半数F1大鼠通过食物接触TBT。通过胎盘和乳汁接触TBT的F1大鼠观察到其行为的抑制作用，并且与对照组相比，它们的体重有所下降。断奶后（3周龄）通过食物接触TBT的F1大鼠与对照组相比，活动和体重也较低。断奶后接触TBT与通过胎盘和母奶接触TBT一样有毒。TBT对行为的抑制作用可能与多巴胺代谢有关，中脑酪氨酸羟化酶、多巴胺转运蛋白和多巴胺受体D2下调。

The neurotoxic effects of tributyltin(TBT) on the F1 rats were examined. The pregnant rats were exposed to TBT via their food, therefore, the F1 rats were exposed to TBT via the placenta and their dam's milk. After weaning, the half of F1 rats were exposed to TBT via their food. The inhibitory effects of behaviors in the F1 rats exposed to TBT via the placenta and their dam's milk were observed as well as the decrease in their body weight compared to the control. The F1 rats exposed to TBT via their food after weaning(at 3 weeks of age) also showed lower activities and body weight compared to the control. The exposure to TBT just after the weaning is toxic as the exposure via the placenta and their dam's milk. The inhibitory effects on the behaviors by TBT may be related to dopamine metabolism, since tyrosine hydorxylase, dopamine transporter and dopamine receptor D2 in the midbrain were down-regulated.