Kinship analysis based on massive SNP genotype data

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The multiplex system of 15 STR loci has been employed in kinship analysis, but its power is insufficient even for sibship. The microarray technique allows us to obtain massive SNP genotype data. As indices for the evaluation based on SNP, the proportion of identical-by-decent(IBD) numbers was preferable, in which linkage disequilibrium and minor allele frequency were conditioned. The minimum number to separate kinship from unrelated pairs was estimated to be approximately 500 and several thousands of SNPs for siblings and the second degree, respectively.