Elucidation of mechanism of cytomegalovirus reactivation and infection in inflammatory bowel disease.
Elucidation of mechanism of cytomegalovirus reactivation and infection in inflammatory bowel disease.
批准号:
21590810
负责人:
NAKASE Hiroshi
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Analysis of function of macrophages infected with cytomegalovirus(CMV). Macrophages, in which CMV was reactivated, strongly produced more pro-inflammatory cytokines in comparison with macrophages with no CMV reactivation. TGF-βdid not inhibit pro-inflammatory cytokine production from macrophages with CMV reactivation because Smad signal transduction was blocked in those cells.(2)Elucidation of mechanism of CMV infection in intestine of IBD. Gene expressions of PDGFR, etc., which could be entry site of CMV, were up-regulated in inflamed colonic mucosa in comparison with non-inflamed colonic mucosa. Interestingly, immunohistochemistry study revealed that CMV is mainly infected in mesenchymal cells of intestine.
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Importance of CXCL16 as a biomarker for granulocytapheresis in patients with Crohn's disease
CXCL16 作为克罗恩病患者粒细胞分离术生物标志物的重要性
DOI:
10.1002/ibd.21657
发表时间:
2011
期刊:
Inflamm Bowel Dis
影响因子:
4.9
作者:
[Nakase H, Uza N, Matsuura M, Chiba T]
通讯作者:
Chiba T
Characteristics of colonoscopic features in patients with ulcerative colitis concomitant with cytomegalovirus reactivation
伴有巨细胞病毒再激活的溃疡性结肠炎患者的结肠镜特征
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Matsuura M, Nakase H, Honzawa Y, Yamamoto S, Matsumura K, Uza N, Chiba T]
通讯作者:
Chiba T
Q&A-専門医に聞くIBDとIBSはどのように違うのですか?
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DOI:
--
发表时间:
2010
期刊:
IBD research
影响因子:
--
作者:
[仲瀬裕志, 本澤有介, 松浦稔, 千葉勉]
通讯作者:
千葉勉
Suppression of LPS-induced NF-kB and p38MAPK activation by FK506 ameliorates murine colitis
FK506 抑制 LPS 诱导的 NF-kB 和 p38MAPK 激活可改善小鼠结肠炎
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Yoshino T, Nakase H, Matsumura K, Yamamoto S, Takeda Y, Ueno S, Uza N, Chiba T]
通讯作者:
Chiba T
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DOI:
--
发表时间:
2010
期刊:
J Gastroenterol Hepatol
影响因子:
--
作者:
[藤本康介, 植松智, 審良静男, Yamamoto S, 増田智先, Yoshino T, Yamamoto S]
通讯作者:
Yamamoto S
共 13 条
Functional analysis of small GTP binding protein Ral in colitis-associated cancer
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批准号:24590941
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2012
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负责人:NAKASE Hiroshi
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依托单位:
New Therapy with CXCL16 Blocking for Inflammatory Bowel Disease
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批准号:18590677
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.32万
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财政年份:2006
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负责人:NAKASE Hiroshi
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依托单位:
Development of New device for Regeneration of small intestinal tissue
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批准号:16590590
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:2004
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负责人:NAKASE Hiroshi
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依托单位:
海外基金