Study of interaction between HCV NS3 protein and host protein

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The secondary structure of the 120 residues of the amino-terminal HCV-1b non-structural region 3 (NS3) deduced from the amino acid sequence was classified into three major groups : A, B and C. The association between this polymorphism and virological response to pegylated interferon plus ribavirin therapy to chronic hepatitis C, or an increased risk of development of hepatocellular carcinoma (HCC), was analyzed. The results suggest that polymorphism in the secondary structure of the HCV-1b NS3 amino-terminal region influences the virological response to pegylated interferon plus ribavirin therapy and an increased risk of HCC, and that virus grouping based on this polymorphism can contribute to prediction of the outcome of chronic HCV infection.