Study of interaction between HCV NS3 protein and host protein

HCV NS3蛋白与宿主蛋白相互作用的研究

• 批准号: 21590824
• 负责人: SAITO Takafumi
• 金额: $ 2.91万
• 依托单位: Yamagata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590824/
• 关键词: C型肝炎; NS3; HCV; 蛋白質; 肝がん; インターフェロン; ウイルス; 二次構造; 治療; 予測因子; 肝細胞がん; HCC; ペグインターフェロン; リバビリン; SVR

The secondary structure of the 120 residues of the amino-terminal HCV-1b non-structural region 3 (NS3) deduced from the amino acid sequence was classified into three major groups : A, B and C. The association between this polymorphism and virological response to pegylated interferon plus ribavirin therapy to chronic hepatitis C, or an increased risk of development of hepatocellular carcinoma (HCC), was analyzed. The results suggest that polymorphism in the secondary structure of the HCV-1b NS3 amino-terminal region influences the virological response to pegylated interferon plus ribavirin therapy and an increased risk of HCC, and that virus grouping based on this polymorphism can contribute to prediction of the outcome of chronic HCV infection.

从氨基酸序列推断的HCV-1 B非结构区3（NS 3）的120个残基的二级结构分为三个主要组：A、B和C。分析了这种多态性与聚乙二醇干扰素加利巴韦林治疗慢性丙型肝炎的病毒学应答或肝细胞癌（HCC）发生风险增加之间的关系。结果表明，HCV-1b NS 3氨基末端区域二级结构的多态性影响聚乙二醇干扰素加利巴韦林治疗的病毒学应答和HCC风险增加，并且基于该多态性的病毒分组有助于预测慢性HCV感染的结局。

项目成果

HCV NS3蛋白質二次構造の多型性とHCV RNA量およびペグインターフェロン・リバビリン併用療法の効果予測の検討

HCV NS3蛋白二级结构多态性检测、HCV RNA水平及聚乙二醇干扰素/利巴韦林联合治疗的疗效预测

• 发表时间: 2009
• 作者: 斎藤貴史;三條麻衣;堀田博;河田純男;他
• 通讯作者: 他

当科における肝硬変の成因別実態

我科按病因分类的肝硬化现状

• 发表时间: 2008
• 作者: 紙屋康之;他;佐々木裕;工藤洋子
• 通讯作者: 工藤洋子

Impact of metabolic syndrome on elevated serum alanine aminotransferase levels in the Japanese population.

• DOI: 10.1016/j.metabol.2009.03.008
• 发表时间: 2009-08
• 期刊: Metabolism: clinical and experimental
• 作者: Takafumi Saito;Y. Nishise;N. Makino;Hiroaki Haga;Rika Ishii;K. Okumoto;Jun-itsu Ito;Hisayoshi Watanabe;Koji Saito;Hiroaki Takeda;H. Togashi;I. Kubota;M. Daimon;T. Kato;S. Kawata

Down-regulation of hepatic stearoyl-CoA desaturase 1 expression by angiotensin II receptor blocker in the obese fa/fa Zucker rat : possible role in amelioration of insulin resistance and hepatic steatosis

血管紧张素 II 受体阻滞剂在肥胖 fa/fa ​​Zucker 大鼠中下调肝硬脂酰辅酶 A 去饱和酶 1 表达：在改善胰岛素抵抗和肝脂肪变性中可能发挥作用

• 发表时间: 2009
• 期刊: Journal of Gastroenterology 44
• 作者: Yokozawa J;Sasaki T;Saito T;et al.
• 通讯作者: et al.

Relationship between Alcohol Consumption and Serum Adiponectin Levels: The Takahata Study-A Cross-Sectional Study of a Healthy Japanese Population

• DOI: 10.1210/jc.2009-1862
• 发表时间: 2010-08-01
• 期刊: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
• 影响因子: 5.8
• 作者: Nishise, Yuko;Saito, Takafumi;Kawata, Sumio
• 通讯作者: Kawata, Sumio