Study of interaction between HCV NS3 protein and host protein

根据推导的氨基酸序列，将丙型肝炎病毒非结构区3(NS3)的120个氨基酸残基的二级结构分为A、B和C三大类，并分析了该基因多态与聚乙二醇化干扰素联合利巴韦林治疗慢性丙型肝炎的病毒学应答或发生肝细胞癌风险增加的关系。结果表明，丙型肝炎病毒-1b NS3氨基末端区域二级结构的多态影响聚乙二醇化干扰素和利巴韦林治疗的病毒学应答和肝癌风险的增加，基于该多态的病毒分组有助于预测慢性丙型肝炎感染的结局。

The secondary structure of the 120 residues of the amino-terminal HCV-1b non-structural region 3 (NS3) deduced from the amino acid sequence was classified into three major groups : A, B and C. The association between this polymorphism and virological response to pegylated interferon plus ribavirin therapy to chronic hepatitis C, or an increased risk of development of hepatocellular carcinoma (HCC), was analyzed. The results suggest that polymorphism in the secondary structure of the HCV-1b NS3 amino-terminal region influences the virological response to pegylated interferon plus ribavirin therapy and an increased risk of HCC, and that virus grouping based on this polymorphism can contribute to prediction of the outcome of chronic HCV infection.