Toll-like receptor expression level on circulating monocyte in cardiomyopathy

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We hypothesized that Toll-like receptor 2(TLR2) expression level on monocytes can be useful as a marker of inflammatory activity in inflammatory cardiomyopathy as a new concept which choronic myocarditis evolves to dilated cardiomyopathy. Thus, we tried to validate our hypothesis by comparing pathological findings of species derived from myocardium with TLR2 expression level on monocytes, but our trial ended up in failure. We could not either verify the usefulness of Toll-like receptor 2 expression level on monocytes for establishing the diagnostic criteria of dilated cardiomyopathy as an inflammatory cardiomyopathy. Although the patients who were diagnosed as cardiac sarcoidosis showed extremely higher level of TLR2, which may suggest that TLR2 expression level on monocytes is identified as a significant contributor for cardiac sarcoidosis. Therefore, high TLR2 expression level on monocytes may be an independent risk factor for cardiac sarcosidosis.