Immunologic Mechanisms in Acute Coronary Syndrome through TRAIL/DR5 pathway

TRAIL/DR5 通路在急性冠脉综合征中的免疫学机制

• 批准号: 21590912
• 负责人: SATO Kayoko
• 金额: $ 2.83万
• 依托单位: Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590912/
• 关键词: 急性冠症候群; 免疫・炎症; アポトーシス; 動脈硬化; 接着分子

Development of atherosclerosis and unstable plaque, which cause acute coronary syndrome(ACS), are highly associated with chronic inflammation and immunological mechanisms. In this study we found that, (1) in unstable plaque, there are abundant TRAIL-positive CD4 T cells, DR5-positive vascular smooth muscle cells and endothelial cells, and apoptosis of target cells induced through the TRAIL/DR5 pathway, (2) inflammatory cytokine TNFαproduced by CD4 T cells increase DR5 and destabilizes plaque, (3) monitoring of soluble TRAIL in peripheral blood is a potential immunological biomarker for assessing plaque stability and disease severity.

动脉粥样硬化和不稳定斑块的发展与慢性炎症和免疫机制密切相关，导致急性冠状动脉综合征（ACS）。本研究发现，（1）在不稳定斑块中，存在大量TRAIL阳性的CD 4 T细胞、DR 5阳性的血管平滑肌细胞和内皮细胞，以及通过TRAIL/DR 5途径诱导的靶细胞凋亡，（2）CD 4 T细胞产生的炎性细胞因子TNFα增加DR 5，使斑块不稳定，（3）监测外周血可溶性TRAIL是评估斑块稳定性和疾病严重程度的潜在免疫学生物标志物。

项目成果

Role of PSGL-1 expressing CD4 T cells in plaque instability

表达 PSGL-1 的 CD4 T 细胞在斑块不稳定中的作用

• 发表时间: 2010
• 作者: Keiko Gomita;Kayoko Sato;Michiaki Higashitani;Fumiaki Mori;Motoji Sawabe;Nobuhisa Hagiwara
• 通讯作者: Nobuhisa Hagiwara

血管生物医学事典第6章25血管疾患と獲得免疫

血管生物医学百科全书第6章第25章血管疾病与获得性免疫

• 发表时间: 2011
• 作者: Keiko Gomita;Kayoko Sato;Kazutaka Kitamura;Motoji Sawabe;Nobuhisa Hagiwara;池田隆徳;小川正浩;浦田秀則;池田隆徳;Hiromichi Wada;佐藤加代子;佐藤加代子
• 通讯作者: 佐藤加代子

Pitavastatin prevents Atherosclerotic Plaque Development via Inhibition of TRAIL Expression on CD4 T Cells

匹伐他汀通过抑制 CD4 T 细胞上 TRAIL 的表达来预防动脉粥样硬化斑块的形成

• 发表时间: 2010
• 作者: Kayoko Sato;Keiko Gomita;Nobuhisa Hagiwara
• 通讯作者: Nobuhisa Hagiwara

High lipoprotein(a) level promotes both coronary atherosclerosis and myocardial infarction: a path analysis using a large number of autopsy cases

• DOI: 10.1136/hrt.2008.160879
• 发表时间: 2009-12-15
• 期刊: HEART
• 影响因子: 5.7
• 作者: Sawabe, M.;Tanaka, N.;Matsushita, S.
• 通讯作者: Matsushita, S.

Age is a Major Pathobiological Determinant of Aortic Dilatation: A Large Autopsy Study of Community Deaths

• DOI: 10.5551/jat.6528
• 发表时间: 2011-01-01
• 期刊: JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
• 影响因子: 4.4
• 作者: Sawabe, Motoji;Hamamatsu, Akihiko;Ozawa, Toshio
• 通讯作者: Ozawa, Toshio