Chronic infection and immune response in COPD patients

我们对93例COPD患者的前瞻性观察研究显示，IgG滴度高的患者的急性发作次数和频繁急性发作（每年至少两次）的发生率明显低于IgG滴度正常的患者。因此，与我们的假设相反，牙周炎相关抗体的正常igg滴度可以是频繁恶化的独立预测因子，这表明体液免疫反应与COPD恶化有关。我们还发现，尽管目前在加重期间进行了额外的治疗，COPD加重仍会加速肺气肿的进展。

Our prospective observational study including 93 COPD patients showed that the numbers of exacerbations and the rate of individuals with frequent exacerbations(at least two per year) were significantly lower in patients with higher IgG titer than those with normal IgG titer. Thus in contrast to our hypothesis, normal-IgG titer for periodontitis-related antibody can be an independent predictor of frequent exacerbations suggesting that humoral immune response associates with COPD exacerbations. We also found that COPD exacerbation accelerated the emphysema progression in spite of current additional therapy during exacerbations.