Chronic infection and immune response in COPD patients

COPD患者的慢性感染与免疫反应

• 批准号: 21590964
• 负责人: MURO Shigeo
• 金额: $ 2.91万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590964/
• 关键词: COPD増悪; 慢性感染; 宿主免疫; 感染; 慢性閉塞性肺疾患; 気道炎症; 歯周病; MAPK

Our prospective observational study including 93 COPD patients showed that the numbers of exacerbations and the rate of individuals with frequent exacerbations(at least two per year) were significantly lower in patients with higher IgG titer than those with normal IgG titer. Thus in contrast to our hypothesis, normal-IgG titer for periodontitis-related antibody can be an independent predictor of frequent exacerbations suggesting that humoral immune response associates with COPD exacerbations. We also found that COPD exacerbation accelerated the emphysema progression in spite of current additional therapy during exacerbations.

我们对93例COPD患者进行的前瞻性观察性研究显示，IgG滴度较高的患者的急性加重次数和频繁急性加重（每年至少2次）的发生率显著低于IgG滴度正常的患者。因此，与我们的假设相反，牙周炎相关抗体的正常IgG滴度可以是频繁加重的独立预测因子，表明体液免疫应答与COPD加重相关。我们还发现，尽管目前在加重期间进行了额外的治疗，但COPD加重加速了肺气肿的进展。

项目成果

胃食道逆流症症状とCOPD増悪

胃食管反流病症状和慢性阻塞性肺病恶化

• 发表时间: 2009
• 作者: D. Kinose;MD;E. Ogawa;MD;PhD;S. Muro;MD;PhD;A. Takahashi;MD;H. Sakai;MD;PhD;W. M. Elliott;PhD;J. C. Hogg;MD;PhD;M. Mishima;MD;PhD
• 通讯作者: PhD

Cough-reflex sensitivity to inhaled capsaicin in COPD associated with increased exacerbation frequency

COPD 患者对吸入辣椒素的咳嗽反射敏感性与加重频率增加相关

• DOI: 10.1111/j.1440-1843.2009.01620.x
• 发表时间: 2009
• 期刊: Respirology
• 影响因子: 6.9
• 作者: Terada K;Muro S;Ohara T;Haruna A;Marumo S;Kudo M;Ogawa E;Hoshino Y;Hirai T;Niimi A;Mishima M
• 通讯作者: Mishima M

A single nucleotide polymorphism in NOD2 gene was associated with pathogenesis and severity of COPD

NOD2基因单核苷酸多态性与COPD的发病机制和严重程度相关

• 发表时间: 2010
• 作者: D. Kinose;E. Ogawa;T. Hirota;I. Ito;S. Muro;Y. Hoshino;T. Hirai;H. Sakai;M. Tamari;M. Mishima
• 通讯作者: M. Mishima

A NOD2 gene polymorphism is associated with the prevalence and severity of chronic obstructive pulmonary disease in a Japanese population

• DOI: 10.1111/j.1440-1843.2011.02069.x
• 发表时间: 2012-01-01
• 期刊: RESPIROLOGY
• 影响因子: 6.9
• 作者: Kinose, Daisuke;Ogawa, Emiko;Mishima, Michiaki
• 通讯作者: Mishima, Michiaki

Three-Dimensional Lobar Distribution of Emphysema Assessed Using Computer Tomographic Data

使用计算机断层扫描数据评估肺气肿的三维肺叶分布

• 发表时间: 2009
• 作者: 福島千鶴;ほか;Three-Dimensional Lobar Distribution of Emphysema Assessed Using Computer Tomographic Data
• 通讯作者: Three-Dimensional Lobar Distribution of Emphysema Assessed Using Computer Tomographic Data