The role of vasopressin V1a receptor in diabetic nephropathy and the invention of new therapy.
加压素V1a受体在糖尿病肾病中的作用及新疗法的发明。
基本信息
- 批准号:21591064
- 负责人:
- 金额:$ 2.91万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2009
- 资助国家:日本
- 起止时间:2009 至 2011
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We reported that vasopressin V1a receptor deficient mice show type 4 renal tubular acidosis, which is characterized by reduced renal function, metabolic acidosis and hyperkalemia. Since the colleting ducts are the main cite of acid secretion by the kidney, we established a new cell line of the intercalated cells(IN-IC cells) from SV40 large T antigen Tg rats. Using these cells, we also found that vasopressin V1a receptor is required for nucleocytoplasmic transport of mineralocorticoid receptor by aldosterone in the intercalated cells. In conclusion, vasopressin V1a receptor is essential for acid-base regulation by aldosterone in intercalated cells. These data suggest the possibility of clinical use of vasopressin V1a receptor antagonist as an aldosterone antagonist.
我们报道了抗利尿激素V1a受体缺陷小鼠表现为4型肾小管酸中毒,其特征是肾功能降低、代谢性酸中毒和高钾血症。由于收集管是肾脏分泌酸的主要通道,我们从SV40大T抗原Tg大鼠身上建立了一种新的插层细胞(IN-IC细胞)细胞系。利用这些细胞,我们还发现加压素V1a受体是嵌入细胞中醛固酮对矿皮质激素受体的核质转运所必需的。综上所述,加压素V1a受体对嵌入细胞中醛固酮的酸碱调节至关重要。这些数据提示抗利尿激素V1a受体拮抗剂作为醛固酮拮抗剂在临床应用的可能性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Acid decreased the expression of Ca-sensing receptor in type-B of mouse kidney collecting duct intercalated cells
酸降低小鼠肾集合管嵌入细胞B型Ca2+敏感受体的表达
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:Yasuoka Y;Sato Y;Izumi Y;Nonoguchi H;Kawahara K
- 通讯作者:Kawahara K
Interaction of aldosterone and vasopressin in the intercalated cells of the collecting ducts
醛固酮和加压素在集合管闰细胞中的相互作用
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:Kahori Hori;et al.
- 通讯作者:et al.
Relation Between Kidney Function, Proteinuria, and Adverse Outcomes
- DOI:10.1001/jama.2010.39
- 发表时间:2010-02-03
- 期刊:
- 影响因子:120.7
- 作者:Hemmelgarn, Brenda R.;Manns, Braden J.;Tonelli, Marcello
- 通讯作者:Tonelli, Marcello
Mechanisms of Type 4(hyperkalemic) Renal Tubular Acidosis
4型(高钾血症)肾小管性酸中毒的机制
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:Hori K;Nagai T;Izumi Y;Nakayama Y;Hasuike Y;Nanami M;Yasuoka Y;Otaki Y;Tanoue A;Kawahara K;Tomita K;Nakanishi T;Nonoguchi H.
- 通讯作者:Nonoguchi H.
High Levels of Tumor Necrosis Factor-α Downregulate Antimicrobial Iron Transport Protein, Nramp1, in Chronic Hemodialysis Patients: A Key Factor for Infection Risk
- DOI:10.1159/000337742
- 发表时间:2012-01-01
- 期刊:
- 影响因子:4.2
- 作者:Moriguchi, Rintarou;Otaki, Yoshinaga;Nakanishi, Takeshi
- 通讯作者:Nakanishi, Takeshi
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NONOGUCHI Hiroshi其他文献
NONOGUCHI Hiroshi的其他文献
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{{ truncateString('NONOGUCHI Hiroshi', 18)}}的其他基金
The mechanisms of regulation of nuclocytoplasmic transport of mineralocorticoid receptor by vasopressin V1a receptor.
加压素 V1a 受体调节盐皮质激素受体核细胞质转运的机制。
- 批准号:
24591244 - 财政年份:2012
- 资助金额:
$ 2.91万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The investigation of the role of interaction of two types of antidiuretic hormone receptors for diuresis and the invention of the new therapy for renal edema.
研究两类抗利尿激素受体相互作用对利尿的作用并发明治疗肾水肿的新疗法。
- 批准号:
19590955 - 财政年份:2007
- 资助金额:
$ 2.91万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Functional analysis of antidiuretic hormone receptor using V1a knockout mice and invention of new diuretics.
V1a基因敲除小鼠抗利尿激素受体功能分析及新型利尿剂的发明。
- 批准号:
17590833 - 财政年份:2005
- 资助金额:
$ 2.91万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The investigation of the mechanisms and therapy of the abnormality in antidiuretic hormone action in patients with chronic renal failure
慢性肾功能衰竭患者抗利尿激素作用异常的机制及治疗探讨
- 批准号:
15590852 - 财政年份:2003
- 资助金额:
$ 2.91万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Regulation of diuresis by 2 types of antidiuretic hormone receptor in chronic renal failure and therapeutic investigation of edema
2种抗利尿激素受体对慢性肾功能衰竭利尿的调节及水肿治疗研究
- 批准号:
13671121 - 财政年份:2001
- 资助金额:
$ 2.91万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The study on molecular biological mechanisms and therapy of sodiam and acid disturbance in renal failure
肾衰竭钠酸紊乱的分子生物学机制及治疗研究
- 批准号:
10671000 - 财政年份:1998
- 资助金额:
$ 2.91万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The investigation of molecular biological mechanisms and therapy of refractory renal edema.
难治性肾水肿的分子生物学机制及治疗研究。
- 批准号:
08671291 - 财政年份:1996
- 资助金额:
$ 2.91万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The investigation of the mechanisms and the rapy of renal edema from the acpect of cell porality.
从细胞多孔性角度探讨肾水肿发生机制及治疗方法。
- 批准号:
06671133 - 财政年份:1994
- 资助金额:
$ 2.91万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
相似海外基金
Regulation of renal Na+ excretion by antidiuretic hormone
抗利尿激素对肾脏Na排泄的调节
- 批准号:
8971624 - 财政年份:2014
- 资助金额:
$ 2.91万 - 项目类别:
Regulation of renal Na+ excretion by antidiuretic hormone
抗利尿激素对肾脏Na排泄的调节
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8836135 - 财政年份:2014
- 资助金额:
$ 2.91万 - 项目类别:
The origin and evolution of the antidiuretic hormone revealed by novel neurohypophysial hormone receptors
新型神经垂体激素受体揭示抗利尿激素的起源和进化
- 批准号:
26291065 - 财政年份:2014
- 资助金额:
$ 2.91万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Regulation of renal Na+ excretion by antidiuretic hormone
抗利尿激素对肾脏Na排泄的调节
- 批准号:
9185963 - 财政年份:2014
- 资助金额:
$ 2.91万 - 项目类别:
Studies on diuretic and antidiuretic hormones in the medically-important insect, Rhodnius prolixus
医学上重要的昆虫Rhodnius prolixus 中利尿和抗利尿激素的研究
- 批准号:
431649-2012 - 财政年份:2012
- 资助金额:
$ 2.91万 - 项目类别:
University Undergraduate Student Research Awards
The investigation of the role of interaction of two types of antidiuretic hormone receptors for diuresis and the invention of the new therapy for renal edema.
研究两类抗利尿激素受体相互作用对利尿的作用并发明治疗肾水肿的新疗法。
- 批准号:
19590955 - 财政年份:2007
- 资助金额:
$ 2.91万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
SR121463B IN PATIENTS W/ SYNDROME INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION
SR121463B 用于抗利尿激素分泌不当综合征患者
- 批准号:
7608484 - 财政年份:2007
- 资助金额:
$ 2.91万 - 项目类别:
Analysis of the action and the mechanism of vasopressin via V1aR in the kidney, and the search for the new antidiuretic peptide
加压素通过V1aR在肾脏中的作用及机制分析及新型抗利尿肽的寻找
- 批准号:
19590957 - 财政年份:2007
- 资助金额:
$ 2.91万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Functional analysis of antidiuretic hormone receptor using V1a knockout mice and invention of new diuretics.
V1a基因敲除小鼠抗利尿激素受体功能分析及新型利尿剂的发明。
- 批准号:
17590833 - 财政年份:2005
- 资助金额:
$ 2.91万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
ループ利尿剤反応性Naトランスポーターの抗利尿ホルモン依存性発現機序の検討
袢利尿反应性钠转运蛋白抗利尿激素依赖性表达机制的研究
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17590816 - 财政年份:2005
- 资助金额:
$ 2.91万 - 项目类别:
Grant-in-Aid for Scientific Research (C)