Pathophysiological roles of heparin cofactor II in cardiac remodeling and insulin resistance

肝素辅因子 II 在心脏重塑和胰岛素抵抗中的病理生理作用

• 批准号: 21591140
• 负责人: AIHARA Ken-ichi
• 金额: $ 2.91万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591140/
• 关键词: ヘパリンコファクターII; トロンビン; 心筋リモデリング; インスリン抵抗性; メタボリックシンドローム; 2型糖尿病

We hypothesized that thrombin inactivation ameliorate cardiac remodeling and diabetes. Angiotensin II accelerated cardiac concentric remodeling and larger left atrial volume with prominent interstitial fibrosis in heparin cofactor II(HCII), an endogenous thrombin inhibitor,-deficient mice than those in wild-type mice. And these cardiac phenotypes were caused by enhancement of NAD(P) H oxidase-transforming growth factor-beta1 pathway. In addition, we found that increased thrombin activity in adipose tissue contributes to the development of insulin resistance via enhancing MCP-1 production, leading to macrophage infiltration and insulin receptor substrate-1-Akt pathway inactivation.

我们假设凝血酶失活改善心脏重塑和糖尿病。血管紧张素II加速心脏向心性重构和较大的左心房容量与突出的间质纤维化肝素辅因子II（HCII），内源性凝血酶抑制剂，缺陷小鼠比野生型小鼠。这些心脏表型是由于NAD（P）H氧化酶-转化生长因子-β 1途径增强所致。此外，我们发现脂肪组织中凝血酶活性的增加通过增加MCP-1的产生，导致巨噬细胞浸润和胰岛素受体底物-1-Akt途径失活而促进胰岛素抵抗的发展。

项目成果

Bosentan Ameliorated Exercise-Induced Pulmonary Arterial Hypertension Complicated with Systemic Sclerosis

• DOI: 10.2169/internalmedicine.49.3812
• 发表时间: 2010-01-01
• 期刊: INTERNAL MEDICINE
• 影响因子: 1.2
• 作者: Yagi, Shusuke;Akaike, Masashi;Sata, Masataka
• 通讯作者: Sata, Masataka

Endothelial Nitric Oxide Synthase-Independent Protective Action of Statin Against Angiotensin II-Induced Atrial Remodeling via Reduced Oxidant Injury

• DOI: 10.1161/hypertensionaha.109.146076
• 发表时间: 2010-04-01
• 期刊: HYPERTENSION
• 影响因子: 8.3
• 作者: Yagi, Shusuke;Akaike, Masashi;Sata, Masataka
• 通讯作者: Sata, Masataka

Heparin cofactor II is a novel anticardiac remodeling factor against angiotensin II excess

肝素辅因子 II 是一种新型的抗血管紧张素 II 过量的抗心脏重塑因子

• 发表时间: 2010
• 作者: 尾崎倫孝;芳賀早苗;森田直樹;深井原;藤堂省;小澤岳昌;近江谷克裕;粟飯原賢一
• 通讯作者: 粟飯原賢一

Decrease in plasma brain natriuretic peptide level in the early phase after the start of carvediolo therapy is a novel predictor of long-term outcome in patients with chronic heart failure.

卡维迪奥洛治疗开始后早期血浆脑钠肽水平下降是慢性心力衰竭患者长期结果的新预测因子。

• 发表时间: 2009
• 期刊: Acta Cardiol 64
• 作者: Fujimura;M
• 通讯作者: M

A role of androgen receptor in ischemia-induced tissue damage and angiogenesis in male

雄激素受体在男性缺血引起的组织损伤和血管生成中的作用

• 发表时间: 2010
• 作者: 吉田守美子;他
• 通讯作者: 他