Role of the G-protein-coupled receptors that sense an extracellular pH in a bone and a joint function

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Extracellular acidification has great influence on a bone and a joint function. Extracellular acidification is occurred at the inflammation parts of arthritis and rheumatism and could have influence on the progression of these diseases. The inflammation responses of macrophages play an important role in the progression of these diseases. In this research, we showed that the G-protein-coupled receptors, which sense an extracellular pH, participate in the inflammation responses of macrophages. The result obtained in this research offers a new knowledge to understand the molecular mechanisms of the progression of these diseases.