The role of plasmin in the regulation of the multiple myeloma microenvironment

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One of the outside cellular regulators are metalloproteinases(MMPs). MMP activation can promote the secretion of hematopoietic growth factors, which in turn drive hematopoietic cell differentiation into e. g. CD11B-positive F4/80 BM-derived cells. These angiopotent cells can be recruited into various tumor beds to further accelerate vasuarization necessary for tumor growth. In addition, these BM-derived cells are major producers of MMPs, creating a vicious cycle accelerating tumor cell growth. In this application, I suggest that proteases can become a novel molecular target in the treatment of blood tumor-related disease treatment including myeloma.