Molecular mechanism of autophagy in follicular lymphoma cells
Molecular mechanism of autophagy in follicular lymphoma cells
批准号:
21591196
负责人:
YOSHIDA Akira
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
We investigated the cell death mechanism of Bcl-2 over expressing human leukemia and lymphoma cells. We found that etoposide treatment increased Beclin-1 expression, the conversion of the soluble form of microtubule-associated protein 1 light chain 3(LC3) to the autophagic vesicle-associated form LC3-II and the occurence of lysosomes/autophagosomes in Bcl-2 over expressing cells. The autophagy inhibitor chloroquine enhanced the cytotoxicity of etoposide in Bcl-2 over expressing lymphoma cells. These data indicate that autophagy may play an important role as protective response after etoposide treatment.
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Camptothecin induces DNA strand breaks and is cytotoxic in stimulated normal lymphocytes
喜树碱会诱导 DNA 链断裂,并对受刺激的正常淋巴细胞具有细胞毒性
DOI:
10.3892/or.2010.1100
发表时间:
2011
期刊:
Oncol Rep
影响因子:
4.2
作者:
[Yamauchi T, Yoshida A, Ueda T]
通讯作者:
Ueda T
Marked Upregulations of Survivin and Aurora-B Kinase Are Associated with Disease Progression in the Myelodysplastic Syndromes
Survivin 和 Aurora-B 激酶的显着上调与骨髓增生异常综合征的疾病进展相关
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Yoshida, A. Zokumasu K., Yamauchi, T., Takagi, K., Kishi, S., Urasaki, Y., Tohyama, K., Ueda T.]
通讯作者:
Ueda T.
Marked upregulation of Survivin and Aurora-B kinase are associated with disease progression in the myelodysplastic syndromes
Survivin 和 Aurora-B 激酶的显着上调与骨髓增生异常综合征的疾病进展相关
DOI:
--
发表时间:
2012
期刊:
Haematologica
影响因子:
10.1
作者:
[Yoshida A, Zokumasu K, Wano Y, Yamauchi T, 他]
通讯作者:
他
Yoshida, A.Zokumasu K., Yamauchi, T., Takagi, K., Kishi, S., Urasaki, Y., Tohyama, K., Ueda T. : Marked Upregulations of Survivin and Aurora-B Kinase Are Associated with Disease Progression in the Myelodysplastic Syndromes
Yoshida, A.Zokumasu K.、Yamauchi, T.、Takagi, K.、Kishi, S.、Urasaki, Y.、Tohyama, K.、Ueda T.:生存素和 Aurora-B 激酶的显着上调与疾病相关
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Yoshida A, Ueda T]
通讯作者:
Ueda T
The indolocarbazole derivative Go6976 suppresses the growth of leukemia cells with FLT3 mutations
吲哚并咔唑衍生物Go6976抑制FLT3突变的白血病细胞的生长
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Yoshida, A, Zokumasu, k., Ueda T]
通讯作者:
Ueda T
共 14 条
Teacher education that contributes to learning science for students
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批准号:19K02818
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2019
-
负责人:YOSHIDA Akira
-
依托单位:
Distributed optimization for HEMS aggregation
-
批准号:18K14170
-
项目类别:Grant-in-Aid for Early-Career Scientists
-
资助金额:$2.58万
-
财政年份:2018
-
负责人:YOSHIDA Akira
-
依托单位:
Study of supporting system construction about second-career development for top athletes
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批准号:22300215
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.32万
-
财政年份:2010
-
负责人:YOSHIDA Akira
-
依托单位:
SUPPRESSION OFFIRE AND GAS EXPLOSION BY WATER MIST
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批准号:22310104
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.4万
-
财政年份:2010
-
负责人:YOSHIDA Akira
-
依托单位:
Temperature receptors in treatment of neurogenic bladder
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批准号:21500479
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2009
-
负责人:YOSHIDA Akira
-
依托单位:
Predictability analysis of explosive cyclones using ensemble assimilation data and an atmospheric general circulation model
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批准号:21740348
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项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$1.5万
-
财政年份:2009
-
负责人:YOSHIDA Akira
-
依托单位:
Primary Teacher Training Program Development to Teach Physics and Chemistry for Promoting Children's Understanding in Elementary School
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批准号:21683009
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项目类别:Grant-in-Aid for Young Scientists (A)
-
资助金额:$13.64万
-
财政年份:2009
-
负责人:YOSHIDA Akira
-
依托单位:
A Study of Ego from the Viewpoints of Phenomenology and Analytic Philosophy
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批准号:20820012
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项目类别:Grant-in-Aid for Young Scientists (Start-up)
-
资助金额:$1.66万
-
财政年份:2008
-
负责人:YOSHIDA Akira
-
依托单位:
Function of thermosensitive receptor in neurogenic bladder
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批准号:19500449
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.41万
-
财政年份:2007
-
负责人:YOSHIDA Akira
-
依托单位:
Evaluation and Verification of Surface Durability of Power Transmission Triboelement Concerning of Micro-and Macro-Configuration
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批准号:17360073
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$6.53万
-
财政年份:2005
-
负责人:YOSHIDA Akira
-
依托单位:
Nano-structure of surface layer formed with green environments chemical polishing solution for aluminum
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批准号:17560641
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2005
-
负责人:YOSHIDA Akira
-
依托单位:
Research on the mechanism of voiding in the neurogenic bladder due to spinal cord injury and cerebral infarction
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批准号:15500371
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2003
-
负责人:YOSHIDA Akira
-
依托单位:
Research and Development of High-Intensity Hydrogen Combustor for Gas Turbine
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批准号:14550199
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.34万
-
财政年份:2002
-
负责人:YOSHIDA Akira
-
依托单位:
Effects of endocrine disrupter chemicals on a novel G-protein-coupled neurosteroid receptor
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批准号:13833005
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.69万
-
财政年份:2001
-
负责人:YOSHIDA Akira
-
依托单位:
Cloning of new endonuclease (AN34) involved in apoptosis.
-
批准号:11670988
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.18万
-
财政年份:1999
-
负责人:YOSHIDA Akira
-
依托单位:
Research on Surface Failure Mechanism and Failure Prediction and Diagnosis of Surface Modified Gears
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批准号:10555052
-
项目类别:Grant-in-Aid for Scientific Research (B).
-
资助金额:$7.68万
-
财政年份:1998
-
负责人:YOSHIDA Akira
-
依托单位:
Extinction of Hydrogen Premixed Flames by Turbulence
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批准号:09650255
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.54万
-
财政年份:1997
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负责人:YOSHIDA Akira
-
依托单位:
Fundamental Study on Surface Durability and Dynamic Performance of Gear with Multiplex Surface Modification
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批准号:09450069
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.15万
-
财政年份:1997
-
负责人:YOSHIDA Akira
-
依托单位:
STUDIES ON LAVOISIER'S EXPERIMENTAL METHOD
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批准号:08680078
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.28万
-
财政年份:1996
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负责人:YOSHIDA Akira
-
依托单位:
Research and Development on Evaluation of Surface Damage and Performance of Gear Pairs under Extreme Environment
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批准号:07505003
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项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$25.98万
-
财政年份:1995
-
负责人:YOSHIDA Akira
-
依托单位:
海外基金