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Molecular mechanism of autophagy in follicular lymphoma cells

Molecular mechanism of autophagy in follicular lymphoma cells
滤泡性淋巴瘤细胞自噬的分子机制
批准号:
21591196
负责人:
YOSHIDA Akira
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
We investigated the cell death mechanism of Bcl-2 over expressing human leukemia and lymphoma cells. We found that etoposide treatment increased Beclin-1 expression, the conversion of the soluble form of microtubule-associated protein 1 light chain 3(LC3) to the autophagic vesicle-associated form LC3-II and the occurence of lysosomes/autophagosomes in Bcl-2 over expressing cells. The autophagy inhibitor chloroquine enhanced the cytotoxicity of etoposide in Bcl-2 over expressing lymphoma cells. These data indicate that autophagy may play an important role as protective response after etoposide treatment.
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Camptothecin induces DNA strand breaks and is cytotoxic in stimulated normal lymphocytes
喜树碱会诱导 DNA 链断裂,并对受刺激的正常淋巴细胞具有细胞毒性
DOI: 10.3892/or.2010.1100
发表时间: 2011
期刊: Oncol Rep
影响因子: 4.2
作者: [Yamauchi T, Yoshida A, Ueda T]
通讯作者: Ueda T
Marked Upregulations of Survivin and Aurora-B Kinase Are Associated with Disease Progression in the Myelodysplastic Syndromes
Survivin 和 Aurora-B 激酶的显着上调与骨髓增生异常综合征的疾病进展相关
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Yoshida, A. Zokumasu K., Yamauchi, T., Takagi, K., Kishi, S., Urasaki, Y., Tohyama, K., Ueda T.]
通讯作者: Ueda T.
Marked upregulation of Survivin and Aurora-B kinase are associated with disease progression in the myelodysplastic syndromes
Survivin 和 Aurora-B 激酶的显着上调与骨髓增生异常综合征的疾病进展相关
DOI: --
发表时间: 2012
期刊: Haematologica
影响因子: 10.1
作者: [Yoshida A, Zokumasu K, Wano Y, Yamauchi T, 他]
通讯作者:
Yoshida, A.Zokumasu K., Yamauchi, T., Takagi, K., Kishi, S., Urasaki, Y., Tohyama, K., Ueda T. : Marked Upregulations of Survivin and Aurora-B Kinase Are Associated with Disease Progression in the Myelodysplastic Syndromes
Yoshida, A.Zokumasu K.、Yamauchi, T.、Takagi, K.、Kishi, S.、Urasaki, Y.、Tohyama, K.、Ueda T.:生存素和 Aurora-B 激酶的显着上调与疾病相关
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Yoshida A, Ueda T]
通讯作者: Ueda T
14
    Teacher education that contributes to learning science for students
    • 批准号:
      19K02818
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.83万
    • 财政年份:
      2019
    • 负责人:
      YOSHIDA Akira
    • 依托单位:
    Distributed optimization for HEMS aggregation
    • 批准号:
      18K14170
    • 项目类别:
      Grant-in-Aid for Early-Career Scientists
    • 资助金额:
      $2.58万
    • 财政年份:
      2018
    • 负责人:
      YOSHIDA Akira
    • 依托单位:
    Study of supporting system construction about second-career development for top athletes
    • 批准号:
      22300215
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.32万
    • 财政年份:
      2010
    • 负责人:
      YOSHIDA Akira
    • 依托单位:
    SUPPRESSION OFFIRE AND GAS EXPLOSION BY WATER MIST
    • 批准号:
      22310104
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.4万
    • 财政年份:
      2010
    • 负责人:
      YOSHIDA Akira
    • 依托单位:
    海外基金