A multicenter study on early diagnosis and prognostic prediction of acute encephalopathy in childhood

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A multicenter study to evaluate urineβ2-microglobulin(BMG) levels at early phase of childhood encephalopathy and related disorders was performed. Among patients with encephalopathy(Group A), complex febrile convulsion(Group B) and abnormal behavior(Group C), mean BMG level was highest in Group A, followed by Group B. However, BMG levels were not significantly different among the 3 groups. Correlation between types of encephalopathy and urine BMG levels was not observed. Most of the patients showing extremely high level of urine BMG had fatal outcome or severe sequelae. Among the patients with encephalopathy, urine BMG levels were significantly higher in fatal cases and cases with severe sequelae, indicating that elevated urine BMG level at early phase was a poor prognostic factor.