Effects of exercise during pregnancy on brain development and learning and emotional behavior in adult offspring and its mechanism

孕期运动对成年后代大脑发育、学习和情绪行为的影响及其机制

• 批准号: 21591416
• 负责人: NAKAMURA Shoji
• 金额: $ 2.83万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591416/
• 关键词: 妊娠; 運動; ストレス; 学習; 情動; 海馬; 八方向放射状迷路学習; 空間学習; 妊娠中の運動; 妊娠中のストレス; 情動の発達; 脳の発達

Effects of exercise during pregnancy on learning and emotional behavior in adult offspring were examined. Pregnant rats were allowed to perform spontaneous running in wheel cage during pregnancy. Learning and emotional behaviors were assessed at 7 to 15 weeks after birth. In addition, using DNA microarray analysis technique, genes affected by exercise during pregnancy were examined. Adult offspring whose dams performed spontaneous running during pregnancy showed increased depression-lile behavior and reduced levels of learning performance. DNA microarray analysis showed that exercise during pregnancy induced a large decrease in brain-derived neurotrophic factor(BDNF) in the hippocampus of adult offspring. These results suggest that spontaneous running during pregnancy causes impairment of learning and emotional behavior, possibly due to reduction in BDNF expression in the hippocampus.

研究了孕期运动对成年后代学习和情感行为的影响。孕鼠在妊娠期间在笼内进行自发性跑步。在出生后7至15周评估学习和情绪行为。此外，利用DNA微阵列分析技术，研究了怀孕期间运动对基因的影响。在怀孕期间进行自发跑步的母鼠的成年后代表现出抑郁倾向的行为增加和学习能力的降低。DNA微阵列分析显示，怀孕期间的运动导致成年后代海马中脑源性神经营养因子（BDNF）的大量减少。这些结果表明，在怀孕期间自发运行会导致学习和情感行为的损害，可能是由于海马中BDNF表达的减少。

项目成果

内側前頭前皮質と扁桃体からなるループ神経回路の電気生理学的解析

内侧前额叶皮层和杏仁核组成的环路神经回路的电生理分析

• 发表时间: 2010
• 作者: Nishimaki S;Sato M;An H;Shima Y;Akaike T;Yokoyama U;Yokota S;石川晃教
• 通讯作者: 石川晃教

EFFECTS OF POSTNATAL ISOLATION REARING AND ANTIDEPRESSANT TREATMENT ON THE DENSITY OF SEROTONERGIC AND NORADRENERGIC AXONS AND DEPRESSIVE BEHAVIOR IN RATS

• DOI: 10.1016/j.neuroscience.2009.06.017
• 发表时间: 2009-09-29
• 期刊: NEUROSCIENCE
• 影响因子: 3.3
• 作者: Kuramochi, M.;Nakamura, S.
• 通讯作者: Nakamura, S.

Proteomic analysis of proteins expressing in regions of rat brain by a combination of SDS-PAGE with nano-liquid chromatography-quadrupole-time of flight tandem mass spectrometry

• DOI: 10.1186/1477-5956-8-41
• 发表时间: 2010-07-27
• 期刊: PROTEOME SCIENCE
• 影响因子: 2
• 作者: Katagiri, Tomoki;Hatano, Naoya;Mizukami, Yoichi
• 通讯作者: Mizukami, Yoichi

Exposure to 1-bromopropane causes degeneration of noradrenergic axons in the rat brain

• DOI: 10.1016/j.tox.2011.04.005
• 发表时间: 2011-07-11
• 期刊: TOXICOLOGY
• 影响因子: 4.5
• 作者: Mohideen, Sahabudeen Sheik;Ichihara, Gaku;Nakamura, Shoji
• 通讯作者: Nakamura, Shoji

The Effects of Three Types of Stress on Fos Expression in the Hypothalamic Paraventricular Nucleus, Hippocampus and Amygdala in Female Rats at Different Stages of Preg- nancy

三种应激对不同妊娠阶段雌性大鼠下丘脑室旁核、海马和杏仁核 Fos 表达的影响

• 发表时间: 2011
• 作者: Masuo Tanaka;S. Hayashi;T. Fujioka;I. Tobe;Shoji Nakamura
• 通讯作者: Shoji Nakamura