Association study of promoter polymorphisms in the dopamine-beta-hydroxylase gene and the dopamine transporter gene with personality traits in healthy subjects

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In this study, we investigated the association of polymorphisms of the dopamine-beta-hydroxylase (DBH) and the dopamine transporter (DAT) with personality traits in healthy Japanese. Personality traits were assessed by Temperament and Character Inventory (TCI), and PCR-RFLP method was used. With regard to the DAT, the females without the A allele of the-67A/T promoter polymorphism had lower scores of self-directedness and cooperativeness than those with the A allele. The intron VNTR polymorphism did not affect any TCI score. Regarding the DBH, the females with the T allele of the-1021C/T promoter polymorphism had higher scores of harm avoidance than those without T allele. The present results suggest that those polymorphisms of the DAT and DBH genes affect personality traits in healthy subjects.