Association study of promoter polymorphisms in the dopamine-beta-hydroxylase gene and the dopamine transporter gene with personality traits in healthy subjects

多巴胺β羟化酶基因和多巴胺转运蛋白基因启动子多态性与健康受试者人格特征的关联研究

• 批准号: 21591480
• 负责人: KAMATA Mitsuhiro
• 金额: $ 1.83万
• 依托单位: Yamagata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591480/
• 关键词: 性格傾向; ドパミントランスポーター; ドパミンβ水酸化酵素(DBH); TCI; DBH; ドパミン-β-水酸化酵素; 遺伝多型; 人格

In this study, we investigated the association of polymorphisms of the dopamine-beta-hydroxylase (DBH) and the dopamine transporter (DAT) with personality traits in healthy Japanese. Personality traits were assessed by Temperament and Character Inventory (TCI), and PCR-RFLP method was used. With regard to the DAT, the females without the A allele of the-67A/T promoter polymorphism had lower scores of self-directedness and cooperativeness than those with the A allele. The intron VNTR polymorphism did not affect any TCI score. Regarding the DBH, the females with the T allele of the-1021C/T promoter polymorphism had higher scores of harm avoidance than those without T allele. The present results suggest that those polymorphisms of the DAT and DBH genes affect personality traits in healthy subjects.

在这项研究中，我们调查了健康日本人多巴胺- β -羟化酶（DBH）和多巴胺转运蛋白（DAT）多态性与人格特质的关系。采用气质性格量表（TCI）和PCR-RFLP方法对被试进行人格特征评估。在DAT方面，不携带67a /T启动子多态性A等位基因的雌性的自我指导性和合作性得分低于携带A等位基因的雌性。内含子VNTR多态性不影响TCI评分。在胸径方面，携带1021c /T启动子多态性T等位基因的雌性比不携带T等位基因的雌性具有更高的伤害回避得分。目前的研究结果表明，DAT和DBH基因的多态性影响健康人的人格特征。

项目成果

Association study between the-102C/T polymorphism of the dopamine-β-hydroxylase gene promoter and personality traits in healthy subjects

多巴胺-β-羟化酶基因启动子-102C/T多态性与健康受试者人格特征的关联研究

• 发表时间: 2009
• 期刊: Neuroscience Letters
• 影响因子: 2.5
• 作者: Kamata M;Suzuki A;Matsumoto Y;Shibuya N;Togashi H;Goto K;Otani K.
• 通讯作者: Otani K.

The-67 A/T promoter polymorphism in the dopamine transporter gene affects personality traits of Japanese females

多巴胺转运蛋白基因中的 The-67 A/T 启动子多态性影响日本女性的人格特征

• 发表时间: 2009
• 期刊: Behavioural Brain Research
• 影响因子: 2.7
• 作者: Shibuya N;Kamata M;Suzuki A;Matsumoto Y;Goto K;Otani K.
• 通讯作者: Otani K.

The -1021C/T polymorphism of the dopamine-β-hydroxylase(DBH)gene promoter affects personality traits in healthy subjects

多巴胺-β-羟化酶（DBH）基因启动子的-1021C/T多态性影响健康受试者的人格特征

• 发表时间: 2011
• 作者: Moriwaki S;et al;鎌田光宏
• 通讯作者: 鎌田光宏

Association study between glucocorticoid receptor gene polymorphisms and personality traits in healthy Japanese subjects

日本健康受试者糖皮质激素受体基因多态性与人格特质的关联研究

• 发表时间: 2012
• 期刊: Psychiatric Genetics
• 影响因子: 0.9
• 作者: Matsumoto Y;Suzuki A;Shibuya A;Sadahiro R;Kamata M;Goto K;Otani K.
• 通讯作者: Otani K.

The-1021C/T polymorphism of the dopamine-β-hydroxylase (DBH) gene promoter affects personality traits in healthy subjects

多巴胺-β-羟化酶（DBH）基因启动子的-1021C/T多态性影响健康受试者的人格特征

• 发表时间: 2011
• 作者: Kamata M;Suzuki A;Sibuya N;Matsumoto Y;Togashi H;Otani K
• 通讯作者: Otani K